Results 151 to 160 of about 84,481 (342)

Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger [PDF]

, 1996
Csaba Szabó, Brian J. Day, Andrew L. Salzman   +2 more
openalex   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

FORMATION OF DIAMAGNETIC PRODUCTS IN CRYSTALLINE NITRATES UNDER THE ACTION OF LIGHT QUANTA WITH THE ENERGY OF 5.58 EV

Вестник Кемеровского государственного университета, 2014
The photolysis of potassium, rubidium and cesium crystalline nitrates under light with the photon energy of 5.58 eV was investigated. Nitrite and peroxynitrite are the photolysis end-products.
L. D. Kriger, M. B. Miklin, V. A. Anan’ev   +2 more
doaj  

Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite [PDF]

, 1996
Vladimir Yermilov, Yumiko Yoshie, Julieta Rubio, Hiroshi Ohshima   +3 more
openalex   +1 more source

Targeting acetylated high mobility group box 1 protein (HMGB1) and toll‐like receptor (TLR4) interaction to alleviate hypertension and neuroinflammation in fructose‐fed rats

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Our previous study reported that fructose intake increased systemic blood pressure and reduced nitric oxide (NO) in the nucleus tractus solitarius (NTS) due to oxidative stress and neuroinflammation. However, it remains unclear how reactive oxygen species (ROS) reduce NO and how this process impacts neuroinflammation in ...
Yu‐Te Lin, Chiu‐Yi Ho, Gwo‐Ching Sun, Tzyy‐Yue Wong, Michael Hsiao, Ching‐Jiunn Tseng, Pei‐Wen Cheng   +6 more
wiley   +1 more source

Oxidants in the Gas Phase of Cigarette Smoke Pass Through the Lung Alveolar Wall and Raise Systemic Oxidative Stress

Journal of Pharmacological Sciences, 2007
Cigarette smoking-induced oxidative stress plays a key role in the pathogenesis of atherosclerosis in smokers. Aqueous cigarette smoke extract (CSE) contains stable oxidants, peroxynitrite-like reactants, which have the ability to oxidize and nitrate low-
Yu Yamaguchi, Fumiko Nasu, Atsuko Harada, Masaru Kunitomo   +3 more
doaj  

Peroxynitrite‐Induced Alterations in Synaptosomal Membrane Proteins [PDF]

, 1999
Tanuja Koppal, Jennifer Drake, Servet Yatin, Brad Jordan, S. Varadarajan, Lori Bettenhausen, D. Allan Butterfield   +6 more
openalex   +1 more source

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Proceedings of the National Academy of Sciences of the United States of America, 1990
J. Beckman, Tanya W. Beckman, Jun Chen, P. Marshall, B. Freeman   +4 more
semanticscholar   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

β-Amyloid Accumulation in Neurovascular Units Following Brain Embolism

Journal of Pharmacological Sciences, 2009
Nitric oxide (NO) toxicity is in part mediated by generation of peroxynitrite with concomitant production of superoxide under pathological brain conditions such as ischemia and Alzheimer’s disease.
Feng Han, Kohji Fukunaga
doaj