Results 11 to 20 of about 76,980 (312)

Potential Benefits of Peroxynitrite [PDF]

The Open Pharmacology Journal, 2008
Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of ...
Bobby D. Nossaman, Philip J. Kadowitz
openalex   +4 more sources

Protection against peroxynitrite [PDF]

FEBS Letters, 1999
Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation.
Arteel, Gavin E., Briviba, Karlis, Sies, Helmut   +2 more
openaire   +2 more sources

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology [PDF]

Proceedings of the National Academy of Sciences, 1998
Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic acid.
D, Salvemini, Z Q, Wang, M K, Stern, M G, Currie, T P, Misko   +4 more
openaire   +2 more sources

Nitric oxide alleviates cadmium- but not arsenic-induced damages in rice roots [PDF]

, 2020
Nitric oxide (NO) has signalling roles in plant stress responses. Cadmium (Cd) and arsenic (As) soil pollutants alter plant development, mainly the root-system, by increasing NO-content, triggering reactive oxygen species (ROS), and forming peroxynitrite
Altamura, M. M., Della Rovere, F., Falasca, G., Fattorini, L., Massimi, L., Piacentini, D., Ronzan, M.   +6 more
core   +1 more source

CARDIOVASCULAR EFFECTS OF PEROXYNITRITE [PDF]

Clinical and Experimental Pharmacology and Physiology, 2007
SUMMARYPeroxynitrite (PN) is formed in biological systems from the reaction of nitric oxide (·NO) with superoxide (·) and both exist as free radicals. By itself, PN is not a free radical, but it can generate nitrogen dioxide (·NO2) and carbonate radical (·) upon reaction with CO2.The reaction of CO2constitutes a major pathway for the disposition of PN ...
Rao M, Uppu, Bobby D, Nossaman, Anthony J, Greco, Alex, Fokin, Subramanyam N, Murthy, Vivian A, Fonseca, Philip J, Kadowitz   +6 more
openaire   +2 more sources

Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation [PDF]

, 2003
Introduction and methods: The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In
Gloe, Torsten, Keller, Matthias, Klauss, Volker, Krötz, Florian, Pohl, Ulrich, Schiele, Thomas M., Sohn, Hae-Young, Theisen, Karl, Zahler, Stefan   +8 more
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Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Pros and cons of current approaches for detecting peroxynitrite and their applications

Biomedical Journal, 2014
Peroxynitrite, a representative of reactive nitrogen species, plays important roles in the physiological and pathological processes of many oxidative stress-related diseases.
Xingmiao Chen, Hansen Chen, Ruixia Deng, Jiangang Shen   +3 more
doaj   +1 more source

Peroxynitrite-induced luminol chemiluminescence [PDF]

Biochemical Journal, 1993
Vascular endothelial cells, smooth muscle cells, macrophages, neutrophils, Kupffer cells and other diverse cell types generate superoxide (O2.-) and nitric oxide (.NO), which can react to form the potent oxidant peroxynitrite anion (ONOO-). Peroxynitrite reacted with luminol to yield chemiluminescence which was greatly enhanced by bicarbonate.
R, Radi, T P, Cosgrove, J S, Beckman, B A, Freeman   +3 more
openaire   +2 more sources