Results 11 to 20 of about 84,481 (342)

Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase

Cells, 2020
We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and reactive oxygen species.
Ali Mahdi, John Tengbom, Michael Alvarsson, Bernhard Wernly, Zhichao Zhou, John Pernow   +5 more
doaj   +2 more sources

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

Molecular Neurobiology, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +2 more sources

Peroxynitrite, a Stealthy Biological Oxidant [PDF]

Journal of Biological Chemistry, 2013
Peroxynitrite is the product of the diffusion-controlled reaction of nitric oxide and superoxide radicals. Peroxynitrite, a reactive short-lived peroxide with a pKa of 6.8, is a good oxidant and nucleophile. It also yields secondary free radical intermediates such as nitrogen dioxide and carbonate radicals.
R. Radi
openaire   +4 more sources

Modulation of Myocardial Contraction by Peroxynitrite [PDF]

Frontiers in Physiology, 2012
Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on ...
Mark eKohr, Steve eRoof, Jay eZweier, Mark T Ziolo   +3 more
doaj   +4 more sources

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology [PDF]

Proceedings of the National Academy of Sciences, 1998
Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic acid.
Daniela Salvemini, Zhiqiang Wang, Michael Stern, Mark G. Currie, Thomas P. Misko   +4 more
openalex   +4 more sources

The Nitration of Proteins, Lipids and DNA by Peroxynitrite Derivatives-Chemistry Involved and Biological Relevance

Stresses, 2022
In recent years, much interest has been generated by the idea that nitrosative stress plays a role in the aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and neurological diseases.
J. M. Pérez de la Lastra, Celia Andrés Juan, F. Plou, Eduardo Perez‐Lebeña   +3 more
semanticscholar   +1 more source

Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Pulmonary hypertension (PH) is a serious disorder with a mortality rate of 40% over 5 y after diagnosis. Endothelial dysfunction is a major contributor to increased pulmonary arterial pressure (PAP) in PH.
Z. Daneva, Corina Marziano, Matteo Ottolini, Y. Chen, Thomas M. Baker, M. Kuppusamy, A. Zhang, Huy Q. Ta, Claire E. Reagan, A. Mihalek, Ramesh B. Kasetti, Yuanjun Shen, B. Isakson, R. Minshall, G. Zode, E. Goncharova, V. Laubach, Swapnil K. Sonkusare   +17 more
semanticscholar   +1 more source

The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Vascular oxidative stress and endothelial cell dysfunction contribute to various human pathologies. Here, we show that, in vascular endothelial cells, a key mitochondrial antioxidant enzyme, namely thioredoxin reductase 2 (TrxR2), plays a ...
P. Kameritsch, M. Singer, Christoph Nuernbergk, Natalia Rios, A. M. Reyes, K. Schmidt, J. Kirsch, Holger Schneider, Susanna Müller, K. Pogoda, Ruicen Cui, T. Kirchner, C. de Wit, Bärbel Lange-Sperandio, U. Pohl, M. Conrad, R. Radi, H. Beck   +17 more
semanticscholar   +1 more source

Protection against peroxynitrite [PDF]

FEBS Letters, 1999
Peroxynitrite formed in vivo from superoxide and nitric oxide can mediate oxidation, nitration, or nitrosation reactions, leading to impaired function, toxicity, and alterations in signaling pathways. Protection against peroxynitrite is important for defense of normal tissue, especially during inflammation.
Helmut Sies, Gavin E. Arteel, Karlis Briviba   +2 more
openaire   +3 more sources

CARDIOVASCULAR EFFECTS OF PEROXYNITRITE [PDF]

Clinical and Experimental Pharmacology and Physiology, 2007
SUMMARYPeroxynitrite (PN) is formed in biological systems from the reaction of nitric oxide (·NO) with superoxide (·) and both exist as free radicals. By itself, PN is not a free radical, but it can generate nitrogen dioxide (·NO2) and carbonate radical (·) upon reaction with CO2.The reaction of CO2constitutes a major pathway for the disposition of PN ...
Anthony J. Greco, Vivian Fonseca, Subramanyam N. Murthy, Alex Fokin, Bobby D. Nossaman, Philip J. Kadowitz, Rao M. Uppu   +6 more
openaire   +3 more sources