Results 11 to 20 of about 36,943 (245)

Peroxynitrite decomposition catalysts: Therapeutics for peroxynitrite-mediated pathology [PDF]

Proceedings of the National Academy of Sciences, 1998
Inflamed tissue is often characterized by the production of NO and superoxide. These radicals react at diffusion-limited rates to form the powerful oxidant peroxynitrite (PN). When protonated, PN decomposes into either nitrate or reactive intermediates capable of mediating tissue damage by oxidation of protein, lipid, and nucleic acid.
Mark G. Currie, Michael K. Stern, Zhi-Qiang Wang, Thomas P. Misko, Daniela Salvemini   +4 more
openaire   +4 more sources

Nanoelectrodes for intracellular measurements of reactive oxygen and nitrogen species in single living cells [PDF]

Current Opinion in Electrochemistry, Elsevier, 2020, 22, pp.44-50, 2020
Reactive oxygen and nitrogen species (ROS and RNS) play important roles in various physiological processes (e.g., phagocytosis) and pathological conditions (e.g., cancer). The primary ROS/RNS, viz., hydrogen peroxide, peroxynitrite ion, nitric oxide, and nitrite ion, can be oxidized at different electrode potentials and therefore detected and ...
arxiv   +1 more source

CARDIOVASCULAR EFFECTS OF PEROXYNITRITE [PDF]

Clinical and Experimental Pharmacology and Physiology, 2007
SUMMARYPeroxynitrite (PN) is formed in biological systems from the reaction of nitric oxide (·NO) with superoxide (·) and both exist as free radicals. By itself, PN is not a free radical, but it can generate nitrogen dioxide (·NO2) and carbonate radical (·) upon reaction with CO2.The reaction of CO2constitutes a major pathway for the disposition of PN ...
Anthony J. Greco, Vivian Fonseca, Subramanyam N. Murthy, Alex Fokin, Bobby D. Nossaman, Philip J. Kadowitz, Rao M. Uppu   +6 more
openaire   +3 more sources

CuATSM effectively ameliorates ALS patient astrocyte‐mediated motor neuron toxicity in human in vitro models of amyotrophic lateral sclerosis

Glia, Volume 71, Issue 2, Page 350-365, February 2023., 2023
Main Points The clinical stage drug CuATSM normalizes aberrant metabolic phenotypes of ALS astrocytes and restores support towards neurons. Patient samples could be stratified based on this phenotype, indicating that the model system might support clinical trial result interpretation or design.
Cassandra N. Dennys, Florence Roussel, Rochelle Rodrigo, Xiaojin Zhang, Andrea Sierra Delgado, Annalisa Hartlaub, Asya Saelim‐Ector, Will Ray, Sarah Heintzman, Ashley Fox, Stephen J. Kolb, Joseph Beckman, Maria Clara Franco, Kathrin Meyer   +13 more
wiley   +1 more source

Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro, Issam Tout, Stéphanie Narguet, Cheikh Mohamed Bed, Morgane Roinard, Ahmad Sleiman, Nathalie Boyer, Nathalie Pons‐Kerjean, Corinne Castelnau, Nathalie Giuly, Dorothy Tonui, Vassili Soumelis, Jamel El Benna, Patrick Soussan, Richard Moreau, Valérie Paradis, Abdellah Mansouri, Tarik Asselah   +17 more
wiley   +1 more source

The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO₂: The Case of Zebrafish Nitrobindin

Antioxidants, 2022
Nitrobindins (Nbs) are all-β-barrel heme proteins and are present in prokaryotes and eukaryotes. Although their function(s) is still obscure, Nbs trap NO and inactivate peroxynitrite.
Giovanna De Simone, Andrea Coletta, Alessandra di Masi, Massimo Coletta, Paolo Ascenzi   +4 more
doaj   +1 more source

Potential Benefits of Peroxynitrite [PDF]

The Open Pharmacology Journal, 2008
Peroxynitrite (PN) is generated by the reaction of nitric oxide (NO) and superoxide in one of the most rapid reactions in biology. Studies have reported that PN is a cytotoxic molecule that contributes to vascular injury in a number of disease states. However, it has become apparent that PN has beneficial effects including vasodilation, inhibition of ...
Philip J. Kadowitz, Bobby D. Nossaman
openaire   +3 more sources

Pros and cons of current approaches for detecting peroxynitrite and their applications

Biomedical Journal, 2014
Peroxynitrite, a representative of reactive nitrogen species, plays important roles in the physiological and pathological processes of many oxidative stress-related diseases.
Xingmiao Chen, Hansen Chen, Ruixia Deng, Jiangang Shen   +3 more
doaj   +1 more source

Local oxidative and nitrosative stress increases in the microcirculation during leukocytes-endothelial cell interactions. [PDF]

PLoS ONE, 2012
Leukocyte-endothelial cell interactions and leukocyte activation are important factors for vascular diseases including nephropathy, retinopathy and angiopathy.
Saptarshi Kar, Mahendra Kavdia
doaj   +1 more source

Moderate hyperuricaemia ameliorated kidney damage in a low‐renin model of experimental renal insufficiency

Basic &Clinical Pharmacology &Toxicology, Volume 132, Issue 1, Page 21-32, January 2023., 2023
Abstract Uric acid has promoted renal fibrosis and inflammation in experimental studies, but some studies have shown nephroprotective effects due to alleviated oxidative stress. We studied the influence of experimental hyperuricaemia in surgically 5/6 nephrectomized rats. Three weeks after subtotal nephrectomy or sham operation, the rats were allocated
Venla Kurra, Arttu Eräranta, Timo Paavonen, Teemu Honkanen, Juhani Myllymäki, Asko Riutta, Ilkka Tikkanen, Päivi Lakkisto, Jukka Mustonen, Ilkka Pörsti   +9 more
wiley   +1 more source