Results 21 to 30 of about 36,943 (245)

Sonochemical formation of peroxynitrite in water: Impact of ultrasonic frequency and power

Ultrasonics Sonochemistry, 2023
There is a lack of literature on peroxynitrite formation due to sonolysis of aerated water. In this work, the impact of sonication parameters, frequency and power, on ultrasonic peroxynitrite production in aerated alkaline water was investigated ...
Hamza Ferkous, Oualid Hamdaoui, Christian Pétrier   +2 more
doaj  

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase

Cells, 2020
We recently showed that red blood cells (RBCs) from patients with type 2 diabetes mellitus (T2DM-RBCs) induce endothelial dysfunction through a mechanism involving arginase I and reactive oxygen species.
Ali Mahdi, John Tengbom, Michael Alvarsson, Bernhard Wernly, Zhichao Zhou, John Pernow   +5 more
doaj   +1 more source

Superoxide and peroxynitrite inatherosclerosis. [PDF]

Proceedings of the National Academy of Sciences, 1994
The role of reactive oxygen species in the vascular pathology associated with atherosclerosis was examined by testing the hypothesis that impaired vascular reactivity results from the reaction of nitric oxide (.NO) with superoxide (O2-), yielding the oxidant peroxynitrite (ONOO-).
Sandra H. Gianturco, D Ku, C R White, James D. Crapo, William A. Bradley, J Z Gore, Ling Yi Chang, Bruce A. Freeman, T A Brock, P Briscoe   +9 more
openaire   +3 more sources

Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation

Redox Biology, 2022
The diffusion-limited reaction of nitric oxide (NO) and superoxide (O2−) produces peroxynitrite (ONOO−), a biological oxidant that has been implicated in a number of pathological conditions, including neurodegenerative disorders.
Megan Jandy, Asra Noor, Pascal Nelson, Cassandra N. Dennys, Isabella M. Karabinas, Jeanine C. Pestoni, Gautam D. Singh, Lam Luc, Rachel Devyldere, Nathalie Perdomo, Catherine E. Mitchell, Levi Adams, Marisa A. Fuse, Francine A. Mendoza, Carrie L. Marean-Reardon, Ryan A. Mehl, Alvaro G. Estevez, Maria Clara Franco   +17 more
doaj  

Peroxynitrite decomposition catalyst prevents apoptotic cell death in a human astrocytoma cell line incubated with supernatants of HIV-infected macrophages

BMC Neuroscience, 2002
Background Oxidative stress has shown to contribute in the mechanisms underlying apoptotic cell death occuring in AIDS-dementia complex. Here we investigated the role of peroxynitrite in apoptosis occurring in astroglial cells incubated with supernatants
Perno Carlo, Rotiroti Domenicantonio, Cufari Antonio, Palma Ernesto, Iannone Michelangelo, Paolino Donatella, Salvemini Daniela, Muscoli Carolina, Aquaro Stefano, Mollace Vincenzo   +9 more
doaj   +1 more source

Elderberries as a potential supplement to improve vascular function in a SARS‐CoV‐2 environment

Journal of Food Biochemistry, Volume 46, Issue 11, November 2022., 2022
Elderberry extract (EE) can target both viral infection and vascular dysfunction which could be a useful strategy to reduce morbidity and mortality relating to COVID‐19. Literature looks promising and builds a suggestion for investigating EE against COVID‐19. However, further in vitro and in vivo research is required to fully evaluate elderberries as a
Joseph Festa, Harprit Singh, Aamir Hussain, Mariasole Da Boit   +3 more
wiley   +1 more source

Bioactive food components and their inhibitory actions in multiple platelet pathways

Journal of Food Biochemistry, Volume 46, Issue 12, December 2022., 2022
A comprehensive overview of platelet multifunctional roles in CVD and other diseases and the effects of food components' modulatory effects are described. Abstract In addition to hemostasis and thrombosis, blood platelets are involved in various processes such as inflammation, infection, immunobiology, cancer metastasis, wound repair and angiogenesis ...
Diptimayee Das, Shubhamay Adhikary, Ranjit Kumar Das, Antara Banerjee, Arun Kumar Radhakrishnan, Sujay Paul, Surajit Pathak, Asim K. Duttaroy   +7 more
wiley   +1 more source

The protective role of Wnt3a in peroxynitrite-induced damage of cochlear hair cells in vitro

Brazilian Journal of Otorhinolaryngology, 2023
Objective: To investigate the effect of peroxynitrite on the cultured cochlear hair cells of C57BL/6 P3 mice in vitro as well as the role of Wnt3a, as an activator of the canonical Wnt signaling pathway, underlying the action of such an oxidative stress.
Fengyun Cui, Zhimin Cao, Qianru Zhang, Zhixin Cao   +3 more
doaj  

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source