Results 31 to 40 of about 70,974 (235)

Nitric oxide from inflammatory origin impairs neural stem cell proliferation by inhibiting epidermal growth factor receptor signaling [PDF]

, 2014
Neuroinflammation is characterized by activation of microglial cells, followed by production of nitric oxide (NO), which may have different outcomes on neurogenesis, favoring or inhibiting this process.
Alvarez-Buylla, Alvaro, Ana I. Santos, Ana S. Lourenço, António F. Ambrósio, Arvidsson, Bal-Price, Batchelor, Beckman, Beltran, Ben-Hur, Benraiss, Bergsland, Boje, Bruno P. Carreira, Buck, Butovsky, Cacci, Caetana M. Carvalho, Calabrese, Calabrese, Cappella, Carreira, Carreira, Chao, Chehrehasa, Covacu, Curtis, Davalos, Dawson, Dawson, Doetsch, Ekdahl, Ekdahl, Eriksson, Estrada, Gage, Galea, Giulian, Green, Guix, Hanafy, Ignarro, Inês M. Araújo, Iosif, Ischiropoulos, Keefer, Kempermann, Kettenmann, Keynes, Lane, Lowenstein, Madhusoodanan, Maria I. Morte, Matarredona, Ming, Misko, Moncada, Monje, Monje, Monteiro, Moreno-Lopez, Murillo-Carretero, Murillo-Carretero, Murphy, Nathan, Nimmerjahn, Ormerod, Packer, Parent, Pryor, Radi, Reynolds, Rock, Salvemini, Saura, Sierra, Szabo, Taupin, Torroglosa, Uc, Vallieres, Walton, Zhang, Zhang, Zhang   +85 more
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TcI isolates of Trypanosoma cruzi exploit the antioxidant network for enhanced intracellular survival in macrophages and virulence in mice [PDF]

, 2016
Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL),
Basombrío, Miguel Ángel Manuel, Dhiman, Monisha, Garg, Nisha J., Hosakote, Yashoda M., Koo, Sue Jie, Parodi­ Talice, Adriana, Piñeyro, María Dolores, Robello, Carlos, Zago, María Paola   +8 more
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Peroxynitrite Inhibits Glutamate Transporter Subtypes [PDF]

Journal of Biological Chemistry, 1996
The reuptake of glutamate in neurons and astrocytes terminates excitatory signals and prevents the persistence of excitotoxic levels of glutamate in the synaptic cleft. This process is inhibited by oxygen radicals and hydrogen peroxide (H2O2). Here we show that another biological oxidant, peroxynitrite (ONOO-), formed by combination of superoxide (O2-)
D. Trotti, D. Rossi, O. Gjesdal, L. Levy, G. Racagni, N. Danbolt, A. Volterra   +6 more
openaire   +4 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
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Adiponectin protects against paraquat-induced lung injury by attenuating oxidative/nitrative stress. [PDF]

, 2014
The specific mechanisms underlying paraquat (PQ)-induced lung injury remain unknown, which limits understanding of its cytotoxic potential. Although oxidative stress has been established as an important mechanism underlying PQ toxicity, multiple ...
Cao, Yu, He, Yarong, Jiang, Yaowen, Lau, Wayne Bond, Liu, Peng, Yao, Rong, Ye, Lei, Zeng, Zhi, Zheng, Zhijie, Zhou, Yaxiong   +9 more
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Superoxide and peroxynitrite inatherosclerosis. [PDF]

Proceedings of the National Academy of Sciences, 1994
The role of reactive oxygen species in the vascular pathology associated with atherosclerosis was examined by testing the hypothesis that impaired vascular reactivity results from the reaction of nitric oxide (.NO) with superoxide (O2-), yielding the oxidant peroxynitrite (ONOO-).
C R, White, T A, Brock, L Y, Chang, J, Crapo, P, Briscoe, D, Ku, W A, Bradley, S H, Gianturco, J, Gore, B A, Freeman   +9 more
openaire   +2 more sources

Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration

Redox Biology, 2018
In this review we provide an analysis of the biochemistry of peroxynitrite and tyrosine nitration. Peroxynitrite is the product of the diffusion-controlled reaction between superoxide (O2•-) and nitric oxide (•NO). This process is in competition with
Silvina Bartesaghi, Rafael Radi
doaj   +1 more source

7-Keto-Cholesterol and Cholestan-3beta, 5alpha, 6beta-Triol Induce Eryptosis through Distinct Pathways Leading to NADPH Oxidase and Nitric Oxide Synthase Activation [PDF]

, 2019
BACKGROUND/AIMS: We showed that patho-physiological concentrations of either 7-keto-cholesterol (7-KC), or cholestane-3beta, 5alpha, 6beta-triol (TRIOL) caused the eryptotic death of human red blood cells (RBC), strictly dependent on the early production
Allegra M., Attanzio A., Cilla A., Frazzitta A., Livrea M. A., Tesoriere L.   +5 more
core   +1 more source

Pterin-6-aldehyde, Xanthine Oxidase Inhibitor and Superoxide Scavenger, Directly React with Peroxynitrite

Pteridines, 1999
The effect of pterin-6-aldehyde (P6A), xanthine oxidase inhibitor and superoxide scavenger, on the production of nitrotyrosine as a footprint of tyrosine nitration by peroxynitrite, was compared with that of uric acid, a peroxynitrite scavenger.
Mori Hiroko, Arai Toshiyuki, Ishii Hisanari, Endo Nobuyuki, Suzuki Toshinori, Fukudal Kazuhiko   +5 more
doaj   +1 more source

Analysis of acid-stressed Bacillus cereus reveals a major oxidative response and inactivation-associated radical formation [PDF]

, 2010
Acid stress resistance of the food-borne human pathogen Bacillus cereus may contribute to its survival in acidic environments, such as encountered in soil, food and the human gastrointestinal tract. The acid stress responses of B.
Abee, T., Kranenburg, R., van, Melis, C.C.J., van, Moezelaar, R., Mols, J.M.   +4 more
core   +2 more sources