Results 51 to 60 of about 606,469 (298)

Unravelling the Roles of Bacterial Nanomachines Bistability in Pathogens’ Life Cycle

Microorganisms
Bacterial nanomachines represent remarkable feats of evolutionary engineering, showcasing intricate molecular mechanisms that enable bacteria to perform a diverse array of functions essential to persist, thrive, and evolve within ecological and ...
Romain Gory, Nicolas Personnic, Didier Blaha   +2 more
doaj   +1 more source

Assistance and Therapy Dogs Are Better Problem Solvers Than Both Trained and Untrained Family Dogs

Frontiers in Veterinary Science, 2020
When faced with unsolvable or difficult situations dogs use different behavioral strategies. If they are motivated to obtain rewards, they either try to solve the problem on their own or tend to interact with a human partner.
Fabricio Carballo, Fabricio Carballo, Camilla María Cavalli, Márta Gácsi, Márta Gácsi, Ádám Miklósi, Ádám Miklósi, Enikő Kubinyi   +7 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

Nature Communications, 2018
In contrast to HIV, simian immunodeficiency viruses (SIV) do not cause disease in their hosts, and the reasons for this are unclear. Here, Joas et al.
Simone Joas, Erica H. Parrish, Clement W. Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Gerald H. Learn, Ulrike Sauermann, Berit Neumann, Kerstin Mätz Rensing, Dietmar Fuchs, James M. Billingsley, Steven E. Bosinger, Guido Silvestri, Cristian Apetrei, Nicolas Huot, Thalia Garcia-Tellez, Michaela Müller-Trutwin, Dominik Hotter, Daniel Sauter, Christiane Stahl-Hennig, Beatrice H. Hahn, Frank Kirchhoff   +22 more
doaj   +1 more source

On a system of $m$ difference equations having exponential terms

Electronic Journal of Qualitative Theory of Differential Equations, 2015
In this paper we study the asymptotic behavior of the positive solutions of a cyclic system of the following $m$ difference equations: \begin{align*} x^{(i)}_{n+1}&=a_ix_n^{(i+1)}+b_i x^{(i)}_{n-1}e^{{-x^{(i+1)}_n}},\qquad i=1,2,\ldots, m-1,\\ x^{(m)}_ ...
Garyfalos Papaschinopoulos, N. Psarros, K.B. Papadopoulos   +2 more
doaj   +1 more source

The persistence of nutrition impact symptoms in cancer survivors’ post-treatment [PDF]

, 2022
Niamh O’Callaghan, P. Douglas, Laura Keaver   +2 more
openalex   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source