Results 81 to 90 of about 583,154 (298)
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
The Effect of Matching on Firm Earnings Components
Scientific Annals of Economics and Business, 2017 Using a sample of all U.S. firms listed on the U.S. major stock exchanges for the period covering 1988 through 2014, we investigate the relation between firm earnings components and matching. Following the methodology of Hui et al.
Cho Joong-Seok, Park Hyung Ju
doaj +1 more source
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
Entry and Degree Attainment in STEM: The Intersection of Gender and Race/Ethnicity
Social Sciences, 2017 This study focused on entry to and attainment of bachelor’s degrees in science, technology, engineering, and mathematics (STEM) fields, by examining gender and race/ethnicity in an intersectional manner and paying particular attention to STEM subfields ...
Yingyi Ma, Yan Liu
doaj +1 more source
The Cambridge Quarterly, 2016 THE NOTION OF BEAUTY, in its various meanings and manifestations, has long fascinated authors and critics. Its appeal fuelled the artistic endeavours of the nineteenth century, captivated its audiences, and haunted the literary movements of the last 100 years.
openaire +2 more sources
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2020 A previous phase 3, randomized, multicenter study showed the immunogenicity of a primary vaccination of subjects aged 11 to 17 years with the quadrivalent meningococcal vaccine conjugated to tetanus toxoid (MenACWY-TT) or the quadrivalent meningococcal ...
Beatriz Quiambao +6 more
doaj +1 more source
Relativism and Persistence [PDF]
Philosophical Studies, 1997 [FIRST PARAGRAPHS] Philosophers often talk as if what it takes for a person to persist through time were up to us,\ud as individuals or as a linguistic community, to decide. In most ordinary situations it might be\ud fully determinate whether someone has survived or perished: barring some unforeseen\ud catastrophe, it is clear enough that you will ...
openaire +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source