Results 91 to 100 of about 82,187 (270)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
, 1987 Determining whether two Petri nets are equivalent is an interesting problem from both practical and theoretical standpoints. Although it is undecidable in the general case, for many interesting nets the equivalence problem is solvable.
Sidwell, Richard D.
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Model for Using DataCite DOIs in Observatory Bibliographies
EPJ Web of Conferences, 2018 The use of DOI persistent identifiers has become an attractive mechanism for citing datasets in articles. However, taking the users’ interests into account requires careful consideration of the way in which we apply these identifiers.
Rots Arnold +2 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The POOL Data Storage, Cache and Conversion Mechanism
, 2003 The POOL data storage mechanism is intended to satisfy the needs of the LHC experiments to store and analyze the data from the detector response of particle collisions at the LHC proton-proton collider.
Dullmann, D. +4 more
core
Persistent Identifiers for Heritage Collections
, 2020 Slides for lightning talk about UKRI funded project on persistent identifiers for heritage collections due to begin in early 2020.
Madden, Frances, Kotarski, Rachael
openaire +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
, 2005 In recent years, a variety of digital repository and archival systems have been developed and adopted. All of these systems aim at hosting a variety of compound digital assets and at providing tools for storing, managing and accessing those assets.
Bekaert, Jeroen, Van de Sompel, Herbert
core +1 more source