Results 101 to 110 of about 24,777 (270)
Persistent Identifier Of Instrumentation
, 2017 Introduction to the instrument identifier ...
openaire +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A blockchain based Trusted Persistent Identifier system for Big Data in Science
Foundations of Computing and Decision Sciences, 2019 A stable reference of Internet resources is crucial not only to identify a resource in a trustworthy and certified way but also to guarantee continuous access to it over time.
Bellini Emanuele
doaj +1 more source
, 2020 This policy states the ARDC’s rationale, intent and broad course of action regarding persistent identifiers (PIDs).
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Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Persistent Identifiers. Why and how?
Introduction to persistent identifiers for early-career researchers. This presentation introduces the most commonly used types of persistent identifiers, explains their purpose, and shows how to use them effectively in ...
Šilha Machová, Hana, Heringová, Hana
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
UK Theses and Persistent Identifiers: A Background
, 2017 <p>Presentation to the EThOS-DataCite UK workshop on 4th December 2017. Providing a background to the Unlocking Theses Data Project and progress on assigning persistent identifiers to doctoral theses in the UK.</p ...
Kotarski, Rachael +1 more
core +1 more source