Results 101 to 110 of about 632,171 (267)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

CrossRef: A Collaborative Linking Network

open access: yesIssues in Science and Technology Librarianship, 2001
References are at the heart of scholarly journal publishing and therefore reference links are seen as an essential feature of online scholarly journals.
Ed Pentz
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Persistent Identifiers @ DANS

open access: yes, 2016
Presentation at CESSDA Workshop: Persistent Identification within ...
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

A blockchain based Trusted Persistent Identifier system for Big Data in Science

open access: yesFoundations of Computing and Decision Sciences, 2019
A stable reference of Internet resources is crucial not only to identify a resource in a trustworthy and certified way but also to guarantee continuous access to it over time.
Bellini Emanuele
doaj   +1 more source

Persistent Identifiers: Considering the Options

open access: yes, 2008
Persistent identifiers (PIs) are simply maintainable identifiers that allow us to refer to a digital object – a file or set of files, such as an e-print (article, paper or report), an image or an installation file for a piece of software.
Tonkin, Emma L
core  

UK Theses and Persistent Identifiers: A Background

open access: yes, 2017
<p>Presentation to the EThOS-DataCite UK workshop on 4th December 2017. Providing a background to the Unlocking Theses Data Project and progress on assigning persistent identifiers to doctoral theses in the UK.</p ...
Kotarski, Rachael   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Using Persistent Identifiers in a research workflow

open access: yes, 2019
Presentation given by Esther Plomp for the PID NL - A workshop on the use of Persistent Identifiers in the Netherlands on the 20th of November in The Hague, The Netherlands.    
Esther Plomp, Esther Plomp (6501731)
core   +1 more source

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