Results 101 to 110 of about 596,197 (256)
Guides to Choosing Persistent Identifiers - Version 3
, 2020 The FREYA Project has compiled short guides to help with choosing persistent identifiers for various types of entities. These are the final version. The first versions were released in May 2020 for community feedback and comment throughout June 2020 ...
Madden, Frances +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A blockchain based Trusted Persistent Identifier system for Big Data in Science
Foundations of Computing and Decision Sciences, 2019 A stable reference of Internet resources is crucial not only to identify a resource in a trustworthy and certified way but also to guarantee continuous access to it over time.
Bellini Emanuele
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
No Persistent Identifiers in the British Library
, 2018 "At present, items in our digital collections do not, as such, have ‘persistent’ identifiers such as digital object identifiers (DOIs), however, we are currently building a new repository, which will enable digital content (collection items, datasets ...
Klaus Graf
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Persistent Identifiers in Germany: Key Findings of a Nationwide Survey
Data Science JournalPersistent identifiers (PIDs) are global, unique, resolvable, and persistent references that have become core components of open science and FAIR research as well as their infrastructures.
Andreas Czerniak +9 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
The Persistent Identifier ecosystem expands – to instruments!
, 2020 A PID or persistent identifier has been in common use in scientific publishing for around 20 years now. It was introduced as a DOI (Digital Object Identifier), and the digital object in this case was the journal article.
openaire +1 more source