Results 101 to 110 of about 6,273 (246)
Mechanism of persister formation in response to nitrogen starvation
Nature CommunicationsBacterial resistance to antibiotics is a major problem, but most chronic infections that are recalcitrant to therapy are caused by drug-susceptible pathogens.
Raleb Taher +7 more
doaj +1 more source
msaABCR operon is involved in persister cell formation in Staphylococcus aureus
BMC Microbiology, 2017 Background Persister cells comprise a phenotypic variant that shows extreme antibiotic tolerance resulting in treatment failures of bacterial infections.
Gyan S. Sahukhal +2 more
doaj +1 more source
Pharmacological agents targeting drug-tolerant persister cells in cancer
Current cancer therapy can be effective, but the development of drug resistant disease is the usual outcome. These drugs can eliminate most of the tumor burden but often fail to eliminate the rare, “Drug Tolerant Persister” (DTP) cell subpopulations in ...
Todd D. Schell +5 more
core +1 more source
Simulated persister generation experiments.
, 2013 Mean and standard deviation in the number of persisters for 10 runs and number of the 10 runs with no persisters recovered (Zeros). The initial number of cells is identical for all sets of simulation.
Bruce R. Levin (105441) +1 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
eLife, 2018 Most bacteria use an indirect pathway to generate aminoacylated glutamine and/or asparagine tRNAs. Clinical isolates of Mycobacterium tuberculosis with increased rates of error in gene translation (mistranslation) involving the indirect tRNA ...
Swarnava Chaudhuri +15 more
doaj +1 more source
Candida albicans biofilms are generally devoid of persister cells
, 2019 International audienceCandida albicans is known for its ability to form biofilms - communities of microorganisms embedded in an extracellular matrix developing on different surfaces. Biofilms are highly tolerant to antifungal therapy. This phenomenon has
Bachellier-Bassi, Sophie +2 more
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Mechanisms for Differential Protein Production in Toxin–Antitoxin Systems
Toxins, 2017 Toxin–antitoxin (TA) systems are key regulators of bacterial persistence, a multidrug-tolerant state found in bacterial species that is a major contributing factor to the growing human health crisis of antibiotic resistance. Type II TA systems consist of
Heather S. Deter +3 more
doaj +1 more source