Results 111 to 120 of about 13,159 (299)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the Persistence of Particles [PDF]

Foundations of Physics, 2005
This paper is about the metaphysical debate whether objects persist over time by the selfsame object existing at different times (nowadays called `endurance' by metaphysicians), or by different temporal parts, or stages, existing at different times (called ` perdurance').
openaire   +3 more sources

Polymyxin B nonapeptide potentiates the eradication of Gram-negative bacterial persisters

Microbiology Spectrum
Antibiotic-resistant Gram-negative bacteria remain a globally leading cause of bacterial infection-associated mortality, and it is imperative to identify novel therapeutic strategies. Recently, the advantage of using antibacterials selective against Gram-
Sun Ju Kim, Jeongwoo Jo, Jihyeon Kim, Kwan Soo Ko, Wonsik Lee   +4 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation

eLife, 2018
Most bacteria use an indirect pathway to generate aminoacylated glutamine and/or asparagine tRNAs. Clinical isolates of Mycobacterium tuberculosis with increased rates of error in gene translation (mistranslation) involving the indirect tRNA ...
Swarnava Chaudhuri, Liping Li, Matthew Zimmerman, Yuemeng Chen, Yu-Xiang Chen, Melody N Toosky, Michelle Gardner, Miaomiao Pan, Yang-Yang Li, Qingwen Kawaji, Jun-Hao Zhu, Hong-Wei Su, Amanda J Martinot, Eric J Rubin, Veronique Anne Dartois, Babak Javid   +15 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Persistable: persistent and stable clustering

Journal of Open Source Software, 2023
Luis Scoccola, Alexander Rolle
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Persistent Mayer homology and persistent Mayer Laplacian

Foundations of Data Science
In algebraic topology, the differential (i.e., boundary operator) typically satisfies $d^{2}=0$. However, the generalized differential $d^{N}=0$ for an integer $N\geq 2$ has been studied in terms of Mayer homology on $N$-chain complexes for more than eighty years. We introduce Mayer Laplacians on $N$-chain complexes.
Shen, Li, Liu, Jian, Wei, Guo-Wei
openaire   +4 more sources

Mini review: Persister cell control strategies [PDF]

Bacterial persisters are growth-arrested cells with low metabolic activities, but have no genetic mutations compared to their parental cells. The dormant nature of persister cells enables them to tolerate high doses of conventional antibiotics and ...
Mohamad Javad Hashemi, Yousr Dhaouadi Khattab, Dacheng Ren   +2 more
core   +1 more source