Results 131 to 140 of about 13,159 (299)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Electrochemical Control of Bacterial Persister Cells
, 2014 The emergence of antibiotic-resistant bacteria has presented an increasing challenge to infection control. Conventional methods of antibacterial treatment involving high dose of antibiotics or surgical intervention have proven insufficient for ...
Niepa, Tagbo Herman Roland
core
Characterizing mycobacterium tuberculosis persister populations.
, 2021 Thesis (PhD)--Stellenbosch University, 2021.ENGLISH ABSTRACT: The adaptation of Mycobacterium tuberculosis in the host contributes to tuberculosis (TB) being one of the leading pulmonary infectious diseases in the world. As infection with M. tuberculosis
Parbhoo, Trisha
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
PERSISTENCE AND ANTI-PERSISTENCE: THEORY AND SOFTWARE
, 2013 Persistent and anti-persistent time series processes show what is called hyperbolic decay. Such series play an important role in the study of many diverse areas such as geophysics and financial economics. They are also of theoretical interest. Fractional Gaussian noise (FGN) and fractionally-differeneced white noise are two widely known examples of ...
openaire +2 more sources
Ampicillin treatment in persister cell studies may cause non-physiological artifacts
Microbial CellPersister cells are a clinically relevant sub-population of an isogenic bacterial culture that is tolerant to bactericidal antibiotics. With the aim to investigate the ribosomal protein content of persister cells, we employed the bacteriolytic properties
Michel Fasnacht +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Persister cells: formation, resuscitation and combative therapies. [PDF]
Persister cells, or superfits, have been strongly implicated in the recalcitrance and recurrence of chronic bacterial infection through the dormant (metabolically reduced) phenotype they display and the tolerance to antimicrobial agents this dormancy ...
Nakouti, I, Wainwright, J, Hobbs, G
core +1 more source
Using BONCAT to dissect the proteome of S. aureus persisters
mSphereBacterial persisters are a subpopulation of cells that exhibit a transient non-susceptible phenotype in the presence of bactericidal antibiotic concentrations. This phenotype can lead to the survival and regrowth of bacteria after treatment, resulting in
Eva D. C. George Matlalcuatzi +7 more
doaj +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source