Results 141 to 150 of about 13,159 (299)
Japan Journal of Industrial and Applied MathematicsAbstractIn persistent homology analysis, interval modules play a central role in describing the birth and death of topological features across a filtration. In this work, we extend this setting, and propose the use of bipath persistent homology, which can be used to study the persistence of topological features across a pair of filtrations connected at
Toshitaka Aoki +2 more
openaire +3 more sources
Impacts of Global Transcriptional Regulators on Persister Metabolism
, 2015 Bacterial persisters are phenotypic variants with an extraordinary capacity to tolerate antibiotics, and they are hypothesized to be a main cause of chronic and relapsing infections.
Orman, Mehmet A. +2 more
core +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Tolerant, Growing Cells from Nutrient Shifts Are Not Persister Cells
, 2017 There is much controversy about the metabolic state of cells that are tolerant to antibiotics, known as persister cells. In this opinion piece, we offer an explanation for the discrepancy seen: some laboratories are studying metabolically active and ...
Thomas K. Wood, Jun-Seob Kim
core +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Persister cells of C. albicans are committed to energy storage.
, 2018 Several enzymes of energy storage pathways are up-regulated in persister cells (indicated in green), whereas glycolysis is down-regulated (indicated in red), suggesting that C. albicans persister cells are adapted to the absence of glucose. Icl1 and Mls1
Patrick Van Dijck (55662) +2 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Classic Spotlight: Persistence Persists [PDF]
Journal of Bacteriology, 2017 openaire +2 more sources
Analyzing Persister Physiology with Fluorescence-Activated Cell Sorting
, 2016 Bacterial persisters are phenotypic variants that exhibit an impressive ability to tolerate antibiotics. Persisters are hypothesized to cause relapse infections, and therefore, understanding their physiology may lead to novel therapeutics to treat ...
Orman, Mehmet A +7 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source