Results 151 to 160 of about 13,159 (299)
Unraveling Mechanisms of Persister Formation during Normal Growth
, 2015 Persisters are phenotypic variants present within bacterial populations that exhibit extreme tolerance toward antibiotic stress and are believed to be responsible for chronic and recurrent infections.
Amato, Stephanie M.
core
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Controlling Bacterial Persister Cells and Biofilms by Synthetic Brominated Furanones
, 2013 Bacteria are well known to obtain tolerance to antibiotics by forming multicellular structures, known as biofilms, and by entering dormancy and forming persister cells.
Pan, Jiachuan
core
Immune system detection of Pseudomonas aeruginosa persister cells
, 2020 Persister cells are a subpopulation of bacterial cells known to be tolerant to antimicrobials. Their reduced susceptibility to antimicrobials allows them to be the source of recurrence of many chronic bacterial infections.
Himmler, Grace Elizabeth
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Persister cell-mediated antimicrobial tolerance in pseudomonas aeruginosa biofilm populations
, 2011 Bacteria preferentially live in biofilms; complex structures of single- or multiple- species of bacteria, surrounded by a self-produced polymeric extracellular matrix and attached to a surface.
Sherwin, Suzanna Jane
core
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Persister Cell Control Mechanisms in Uropathogenic Escherichia coli
, 2015 Persister cells are a subpopulation of bacteria that demonstrate high tolerance to antibiotics, but revert to sensitivity after antibiotics are removed.
Law, William H, III
core
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source