Results 51 to 60 of about 6,273 (246)

Combatting persister cells: The daunting task in post-antibiotics era

, 2023
Over the years, much attention has been drawn to antibiotic resistance bacteria, but drug inefficacy caused by a subgroup of special phenotypic variants – persisters – has been largely neglected in both scientific and clinical field.
Hebin Liao, Linsen Pei, Yidan Zhou, Yingying Pu   +3 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

Selective context, rather than persister cycling alone, drives resistance fixation in Escherichia coli

npj Antimicrobials and Resistance
Whether persister cells contribute to the evolution of antibiotic resistance and, if so, under what selective conditions this occurs, remain unresolved.
Garin Park, Hyein Kim, Sooyeon Song
doaj   +1 more source

Association of pth Variants with Elevated Persister Fractions in Clinical Escherichia coli Isolates

Pathogens
Persister cells pose severe threats and serve as the primary drivers of chronic and recurrent infections. Nevertheless, clinical laboratories rarely quantify persister fractions of pathogenic bacteria due to the limited number of detection approaches and
Lei Xu, Jinxi Yue, Bingxue Ning, Kangxinhe Zhang, Guoyang He, Manqi Xiao, Zixuan Zhang, Xinyi Zheng, Xiaodan Yan, Hebin Liao   +9 more
doaj   +1 more source

The Persistence of Warps [PDF]

Symposium - International Astronomical Union, 1979
Hunter and Toomre (1969) have demonstrated that a simple warp of a stellar disk will damp out within one or two galactic rotation periods due to rapid differential recession of stellar orbits. If, however, the galactic gravitational field is more nearly spherically symmetric, the rate of differential recession is decreased and the warp may persist for ...
Allan D. Tubbs, Robert H. Sanders
openaire   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Persistent progress [PDF]

Cell, 2021
The highly effective and safe mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines draw on decades of painstaking research to overcome the many hurdles for delivering, expressing, and avoiding toxicity of therapeutic mRNA. Cell editor Nicole Neuman talked with Dr. Katalin Karikó and Dr.
openaire   +2 more sources

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Antibiotic Resistance and Presence of Persister Cells in the Biofilm-like Environments in Streptococcus agalactiae

Antibiotics
Objectives: This study investigated antibiotic resistance and presence of persister cells in Streptococcus agalactiae strains belonging to capsular types Ia/ST-103, III/ST-17, and V/ST-26 in biofilm-like environments. Results: S.
Pamella Silva Lannes-Costa, Isabelle Rodrigues Fernandes, João Matheus Sobral Pena, Brunno Renato Farias Verçoza Costa, Marcel Menezes Lyra da Cunha, Bernadete Teixeira Ferreira-Carvalho, Prescilla Emy Nagao   +6 more
doaj   +1 more source