Results 71 to 80 of about 13,159 (299)
Understanding Cancer Persister Cell Vulnerabilities and Mutagenesis
, 2021 The landscape of cancer treatment options has grown to include more precise and less invasive strategies. However, acquired drug resistance often results in transient responses.
Stuhlfire, Anna Elizabeth
core
ISME Communications, 2022 Enteric pathogens can enter a persister state in which they survive exposure to antibiotics and physicochemical stresses. Subpopulations of such phenotypic dormant variants have been detected in vivo and in planta in the laboratory, but their formation ...
Maria T. Brandl +7 more
doaj +1 more source
The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
Persistent Identification of Instruments
Data Science Journal, 2020 Instruments play an essential role in creating research data. Given the importance of instruments and associated metadata to the assessment of data quality and data reuse, globally unique, persistent and resolvable identification of instruments is crucial.
Markus Stocker +7 more
openaire +9 more sources
A New Strategy for Persister Control
, 2023 Eradicating persistent bacterial infections is an ever-growing problem in the medical field. Conventional antibiotics are becoming less effective against persistent infections in tuberculosis, cystic fibrosis, Lyme disease, device-associated, urinary ...
Roy, Sweta
core
msaABCR operon is involved in persister cell formation in Staphylococcus aureus
BMC Microbiology, 2017 Background Persister cells comprise a phenotypic variant that shows extreme antibiotic tolerance resulting in treatment failures of bacterial infections.
Gyan S. Sahukhal +2 more
doaj +1 more source
Pathogens, 2023 The appearance of persister cells with low metabolic rates are key factors leading to antibiotic treatment failure. Such persisters are multidrug tolerant and play a key role in the recalcitrance of biofilm-based chronic infections.
Amr A. Baiomy +7 more
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi +5 more
wiley +1 more source
Frequency distribution of the persister fractions.
, 2013 Persister producer strains were grouped in 6 classes (defined by the square root of sample size) according to their persister fraction in the population after polymyxin B (a) or tobramycin (b) exposure.
Sílvia Dias de Oliveira (504159) +6 more
core +1 more source
Frontiers in PharmacologyIntroductionPersistent infections remain challenging due to dormant bacterial cells that tolerate conventional antibiotics. Specifically, persister cells, phenotypic variants characterized by high antibiotic tolerance, can resume growth once antibiotic ...
Yufei Sun +6 more
doaj +1 more source