Results 61 to 70 of about 13,159 (299)

Isolation of persister cells within the biofilm and relative gene expression analysis of type II toxin/antitoxin system in Pseudomonas aeruginosa isolates in exponential and stationary phases

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Chronic infections and treatment failure are concerning issues in patients with Pseudomonas aeruginosa infections. Persister cell formation in biofilm is considered a key reason for antibiotic resistance and treatment failure.
Rezvan Golmoradi Zadeh, Behrooz Sadeghi Kalani, Marzie Mahdizade Ari, Malihe Talebi, Shabnam Razavi, Faramarz Masjedian Jazi   +5 more
doaj   +1 more source

The Persistence of Warps [PDF]

Symposium - International Astronomical Union, 1979
Hunter and Toomre (1969) have demonstrated that a simple warp of a stellar disk will damp out within one or two galactic rotation periods due to rapid differential recession of stellar orbits. If, however, the galactic gravitational field is more nearly spherically symmetric, the rate of differential recession is decreased and the warp may persist for ...
Allan D. Tubbs, Robert H. Sanders
openaire   +1 more source

Persister and non-persister cells and their respective descendants through time considering τ0 = 30, k1 = 0.1, k2 = 0.01.

, 2021
Results of simulations when we assumed that the persister population decays according to an exponential and that persister cells leave the dormant state as soon as the medium becomes detoxified. (DOCX)
Teresa Nogueira (118513), João S. Rebelo (11378420), Francisco Dionisio (185482), Francisca Monteiro (3196734), Célia P. F. Domingues (11378423)   +4 more
core   +1 more source

Antibiotic Resistance and Presence of Persister Cells in the Biofilm-like Environments in Streptococcus agalactiae

Antibiotics
Objectives: This study investigated antibiotic resistance and presence of persister cells in Streptococcus agalactiae strains belonging to capsular types Ia/ST-103, III/ST-17, and V/ST-26 in biofilm-like environments. Results: S.
Pamella Silva Lannes-Costa, Isabelle Rodrigues Fernandes, João Matheus Sobral Pena, Brunno Renato Farias Verçoza Costa, Marcel Menezes Lyra da Cunha, Bernadete Teixeira Ferreira-Carvalho, Prescilla Emy Nagao   +6 more
doaj   +1 more source

Quorum Sensing-Regulated Phenol-Soluble Modulins Limit Persister Cell Populations in Staphylococcus aureus

Frontiers in Microbiology, 2018
Incomplete killing of bacterial pathogens by antibiotics is an underlying cause of treatment failure and accompanying complications. Among those avoiding chemotherapy are persisters being individual cells in a population that for extended periods of time
Martin S. Bojer, Martin S. Bojer, Søren Lindemose, Martin Vestergaard, Hanne Ingmer, Hanne Ingmer   +5 more
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Persistent progress [PDF]

Cell, 2021
The highly effective and safe mRNA-based severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines draw on decades of painstaking research to overcome the many hurdles for delivering, expressing, and avoiding toxicity of therapeutic mRNA. Cell editor Nicole Neuman talked with Dr. Katalin Karikó and Dr.
openaire   +2 more sources

The role of metabolism in bacterial persistence

Frontiers in Microbiology, 2014
Bacterial persisters are phenotypic variants with extraordinary tolerances toward antibiotics. Persister survival has been attributed to inhibition of essential cell functions during antibiotic stress, followed by reversal of the process and resumption ...
Stephanie M. Amato, Christopher H. Fazen, Theresa C. Henry, Theresa C. Henry, Wendy W. K. Mok, Mehmet A. Orman, Elizabeth L. Sandvik, Katherine G. Volzing, Mark P. Brynildsen, Mark P. Brynildsen   +9 more
doaj   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source