Results 141 to 150 of about 616,389 (323)
On the Persistence of Particles [PDF]
Foundations of Physics, 2005 This paper is about the metaphysical debate whether objects persist over time by the selfsame object existing at different times (nowadays called `endurance' by metaphysicians), or by different temporal parts, or stages, existing at different times (called ` perdurance').
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Metronidazole-tolerant Porphyromonas gingivalis persisters dampen cytokine expression in HGECs
, 2019 Objectives: Our group has recently demonstrated the existence of metronidazole-tolerant Porphyromonas gingivalis persisters. This study further investigated the effects of P.
Li, X, Jin, L, Cheng, T, Wang, C
core
Single-cell Raman spectroscopy identifies E. coli persisters and their functionalities
, 2021 Objectives: Microbial persisters are the featured tiny sub-population of microorganisms highly tolerant to multiple antimicrobials. Currently, studies on persisters remain challenging owing to technical limitations.
Xu, J, Jin, L, Chen, R, Wang, C
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Persistable: persistent and stable clustering
Journal of Open Source Software, 2023 Luis Scoccola, Alexander Rolle
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, 2018 Bacterial persisters, a dormant and multidrug tolerant subpopulation that are able to resuscitate after antibiotic treatment, have recently received considerable attention as a major cause of relapse of various infectious diseases in the clinic. However,
Lam, Henry +2 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Persistent Mayer homology and persistent Mayer Laplacian
Foundations of Data ScienceIn algebraic topology, the differential (i.e., boundary operator) typically satisfies $d^{2}=0$. However, the generalized differential $d^{N}=0$ for an integer $N\geq 2$ has been studied in terms of Mayer homology on $N$-chain complexes for more than eighty years. We introduce Mayer Laplacians on $N$-chain complexes.
Shen, Li, Liu, Jian, Wei, Guo-Wei
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source