Results 151 to 160 of about 616,389 (323)
persisters using an FDA approved drug library
, 2014 Although antibiotic treatment for Lyme disease is effective in the majority of cases, especially during the early phase of the disease, a minority of patients suffer from post-treatment Lyme disease syndrome (PTLDS).
Jie Feng +6 more
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Relativism and Persistence [PDF]
Philosophical Studies, 1997 [FIRST PARAGRAPHS] Philosophers often talk as if what it takes for a person to persist through time were up to us,\ud as individuals or as a linguistic community, to decide. In most ordinary situations it might be\ud fully determinate whether someone has survived or perished: barring some unforeseen\ud catastrophe, it is clear enough that you will ...
openaire +2 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Proton motive force and antibiotic tolerance in bacteria
Microbial BiotechnologyBacterial antibiotic tolerance is a decades‐old phenomenon in which a bacterial sub‐population, commonly known as persisters, does not respond to antibiotics and remains viable upon prolonged antimicrobial treatment.
Yingkun Wan +3 more
doaj +1 more source
Supplementary Material for: Staphylococcus aureus Persisters Tolerant to Bactericidal Antibiotics
, 2017 Bacterial persister cells are non- or slow-growing reversible phenotypic variants of the wild type, tolerant to bactericidal antibiotics. We analyzed here Staphylococcus aureus persister levels by monitoring colony-forming unit counts of planktonically ...
Bertram R. (3835897) +2 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Bismuth plus metronidazole synergistically dampens Porphyromonas gingivalis persisters formation
, 2020 Objectives: P. gingivalis is the ‘keystone’ periodontopathogen. Our group has recently demonstrated that metronidazole-treated P. gingivalis persisters invade human gingival epithelial cells (HGECs) and perturb innate host response, and yet bismuth drugs
Jin, L, Cheng, T, Wang, C
core
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals
, 2019 During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model capable of yielding a phenotypically
Chand, Nikhilesh S. +4 more
core +1 more source