Results 171 to 180 of about 616,389 (323)

Heterogeneous survival upon disinfection underlies evolution of increased tolerance

Microbiology Spectrum
Disinfection is important to limit the spread of infections, but failure of disinfection may foster the evolution of antimicrobial resistance in bacteria.
Niclas Nordholt, Lydia-Yasmin Sobisch, Annett Gödt, Dominique Lewerenz, Frank Schreiber   +4 more
doaj   +1 more source

Hypoionic shock treatment enables aminoglycosides antibiotics to eradicate bacterial persisters

, 2015
Bacterial persisters, usually being considered as dormant cells that are tolerant to antibiotics, are an important source for recurrent infection and emergence of antibiotic resistant pathogens.
Fu, Xinmiao, Liu Jiafeng, Chang, Zengyi
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Cysteine Potentiates Bactericidal Antibiotics Activity Against Gram-Negative Bacterial Persisters

Infection and Drug Resistance, 2020
Yuan Liu,1– 3 Kangni Yang,1 Yuqian Jia,1 Jingru Shi,1 Ziwen Tong,1 Zhiqiang Wang1,2 1College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Jiangsu Co-Innovation Center for Prevention and Control ...
Liu Y, Yang K, Jia Y, Shi J, Tong Z, Wang Z   +5 more
doaj  

Antimicrobial tolerance of Porphyromonas gingivalis and Candida albicans persisters : molecular profiles, underlying mechanisms and perspectives

, 2016
Antimicrobial tolerance of microbial persisters has increasingly become a critical challenge for effective prevention and control of infectious/inflammatory diseases worldwide.
李鵬, Li, Peng
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Classic Spotlight: Persistence Persists [PDF]

Journal of Bacteriology, 2017
openaire   +2 more sources

The eradication of bacterial persisters with antibiotic-generated hydroxyl radical

, 2012
During Mycobacterium tuberculosis infection, a population of bacteria likely becomes refractory to antibiotic killing in the absence of genotypic resistance, making treatment challenging. We describe an in vitro model capable of yielding a phenotypically
Chand, Nikhilesh S., Hung, Deborah T., Grant, Sarah Schmidt, Haseley, Nathan Scott, Kaufmann, Benjamin B.   +4 more
core   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source