Results 161 to 170 of about 1,944 (186)
Some of the next articles are maybe not open access.
Esterase-Sensitive Glutathione Persulfide Donor
Organic Letters, 2018An esterase-sensitive glutathione persulfide (GSSH) donor (BW-GP-401) is described. The release profile was studied by monitoring the formation of lactone and direct trapping of GSSH with 1-fluoro-2,4-dinitrobenzene (DNFB). The donor was examined for its inhibitory effect toward glyceraldehyde 3-phosphate dehydrogenase (GAPDH).
Zhengnan Yuan +5 more
openaire +2 more sources
Journal of the American Chemical Society, 2017
A general strategy of delivering hydrogen persulfide (H2S2) is described herein. Esterase- and phosphatase-sensitive H2S2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H2S2, our findings reaffirmed that S-persulfidation leads ...
Bingchen Yu +9 more
openaire +2 more sources
A general strategy of delivering hydrogen persulfide (H2S2) is described herein. Esterase- and phosphatase-sensitive H2S2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H2S2, our findings reaffirmed that S-persulfidation leads ...
Bingchen Yu +9 more
openaire +2 more sources
Protein Persulfidation: Recent Progress and Future Directions
Antioxidants & Redox Signaling, 2023Significance: Hydrogen sulfide (H2S) is considered to be a gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO), and is known as a key regulator of physiological and pathological activities. S-sulfhydration (also known as persulfidation), a mechanism involving the formation of protein persulfides by modification of cysteine residues ...
Shanshan Luo +8 more
openaire +2 more sources
ProPerDP: A Protein Persulfide Detection Protocol
2019Persulfide or polysulfide formation on Cys residues is emerging as an abundant protein posttranslational modification, with important regulatory functions. However, as many other Cys oxidative modifications, per- and polysulfides are relatively labile, dynamically interchanging species, which makes their intracellular detections challenging.
Éva, Dóka +3 more
openaire +2 more sources
Acidity and nucleophilic reactivity of persulfides
The FASEB Journal, 2022Persulfides(RSSH/RSS ‐ ) are chemical compounds related to thiols (RSH) and hydrogen sulfide (H 2 S). They participate in sulfur trafficking and processing, and are proposed to be transducers of the signaling effects of H 2
Dayana Benchoam +3 more
openaire +1 more source
Biochemical Functions of Persulfides
1982In biological systems, persulfides (RSS-) are reactive, unstable intermediates in the transformations of sulfur compounds. Persulfides are also referred to as polysulfides, or alkyl/aryl hydrogen disulfides. The persulfide sulfur is commonly termed, “sulfane”, to designate sulfur covalently bonded only to other sulfur atoms.
openaire +2 more sources
Persulfidation (S-sulfhydration) and H2S
2015The past decade has witnessed the discovery of hydrogen sulfide (H2S) as a new signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure, immunomodulator or anti-apoptotic agent, together with its great pharmacological potential, is now well established.
openaire +2 more sources
Thiiranes: Intelligent Molecules for S-Persulfidation
Journal of the American Chemical SocietyThis study presents a global strategy for the transsulfuration of intracellular thiols (RSH) to persulfides (RSSH). Thiiranes comprising fluorenyl/diphenyl and malonate ester moieties directly convert intercellular RSH to low-molecular-weight RSSH in cells.
Hoe-In Kim +6 more
openaire +2 more sources
Biological chemistry of hydrogen sulfide and persulfides
Archives of Biochemistry and Biophysics, 2017Hydrogen sulfide (H2S) has been traditionally considered to be a toxic molecule for mammals. However, it can be formed endogenously and exert physiological effects with potential health benefits. H2S can partition two-fold in biological membranes and traverse them rapidly, diffusing between compartments.
Ernesto, Cuevasanta +2 more
openaire +2 more sources
A modified protein persulfidation detection method
Acta Physiologiae Plantarum, 2020As a gastransmitter, hydrogen sulfide (H2S) plays an important role in regulating plant growth and stress resistance. The proposed functional mechanism of H2S is persulfidation, a kind of posttranslational modification on free cysteine residues of proteins, which is also called S-sulfhydration previously. At present, biotin switch assay is an effective
Z. Q. Liu +5 more
openaire +1 more source