Results 131 to 140 of about 2,511 (170)

Persulfidation-induced structural change in SnRK2.6 establishes intramolecular interaction between phosphorylation and persulfidation

Molecular Plant, 2021
Post-translational modifications (PTMs), including phosphorylation and persulfidation, regulate the activity of SNF1-RELATED PROTEIN KINASE2.6 (SnRK2.6). Here, we report how persulfidations and phosphorylations of SnRK2.6 influence each other. The persulfidation of cysteine C131/C137 alters SnRK2.6 structure and brings the serine S175 residue closer to
Sisi Chen, Xiaofeng Wang, Honglei Jia, Fali Li, Ying Ma, Johannes Liesche, Mingzhi Liao, Xueting Ding, Cuixia Liu, Ying Chen, Na Li, Jisheng Li   +11 more
openaire   +2 more sources

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems [PDF]

Science Advances, 2016
Protein Persulfide Detection Protocol reveals vital roles for thioredoxin and glutathione systems in maintaining sulfane sulfur homeostasis in cells and in vivo.
Qing Cheng, Elias Arner, Eva Doka
exaly   +5 more sources

Acidity and nucleophilic reactivity of persulfides

The FASEB Journal, 2022
Persulfides(RSSH/RSS ‐ ) are chemical compounds related to thiols (RSH) and hydrogen sulfide (H 2 S). They participate in sulfur trafficking and processing, and are proposed to be transducers of the signaling effects of H 2
Dayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, Beatriz Alvarez   +3 more
openaire   +1 more source

ProPerDP: A Protein Persulfide Detection Protocol

Methods in Molecular Biology, 2019
Persulfide or polysulfide formation on Cys residues is emerging as an abundant protein posttranslational modification, with important regulatory functions. However, as many other Cys oxidative modifications, per- and polysulfides are relatively labile, dynamically interchanging species, which makes their intracellular detections challenging.
Elias Arner, Eva Doka, Ed Schmidt
exaly   +3 more sources

Toward Direct Protein S-Persulfidation: A Prodrug Approach That Directly Delivers Hydrogen Persulfide

Journal of the American Chemical Society, 2017
A general strategy of delivering hydrogen persulfide (H2S2) is described herein. Esterase- and phosphatase-sensitive H2S2 prodrugs with tunable release rates have been synthesized. Their utility is validated in examining protein S-persulfidation. With this unique approach of directly delivering H2S2, our findings reaffirmed that S-persulfidation leads ...
Bingchen Yu, Yueqin Zheng, Zhengnan Yuan, Shanshan Li, He Zhu, Ladie Kimberly De La Cruz, Jun Zhang, Kaili Ji, Siming Wang, Binghe Wang   +9 more
openaire   +2 more sources

Targeted Delivery of Persulfides to the Gut: Effects on the Microbiome

Angewandte Chemie, 2021
AbstractPersulfides (R−SSH) have been hypothesized as potent redox modulators and signaling compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a persulfide donor that releases N‐acetyl cysteine persulfide (NAC‐SSH) in response to the prokaryote‐specific enzyme nitroreductase.
Kearsley M. Dillon, Holly A. Morrison, Chadwick R. Powell, Ryan J. Carrazzone, Veronica M. Ringel‐Scaia, Ethan W. Winckler, R. McAlister Council‐Troche, Irving C. Allen, John B. Matson   +8 more
openaire   +2 more sources

Biochemical Functions of Persulfides

1982
In biological systems, persulfides (RSS-) are reactive, unstable intermediates in the transformations of sulfur compounds. Persulfides are also referred to as polysulfides, or alkyl/aryl hydrogen disulfides. The persulfide sulfur is commonly termed, “sulfane”, to designate sulfur covalently bonded only to other sulfur atoms.
openaire   +2 more sources

Biological chemistry of hydrogen sulfide and persulfides

Archives of Biochemistry and Biophysics, 2017
Hydrogen sulfide (H2S) has been traditionally considered to be a toxic molecule for mammals. However, it can be formed endogenously and exert physiological effects with potential health benefits. H2S can partition two-fold in biological membranes and traverse them rapidly, diffusing between compartments.
Ernesto, Cuevasanta, Matías N, Möller, Beatriz, Alvarez   +2 more
openaire   +2 more sources

Protein Persulfidation: Recent Progress and Future Directions

Antioxidants & Redox Signaling, 2023
Significance: Hydrogen sulfide (H 2 S) is considered to be a gasotransmitter along with carbon monoxide (CO) and nitric oxide (NO), and is known as a key regulator of physiological and pathological activities.
Shanshan Luo, Chuiyu Kong, Danyu Ye, Xingeng Liu, Yu Wang, Guoliang Meng, Yi Han, Liping Xie, Yong Ji   +8 more
openaire   +2 more sources

Persulfidation (S-sulfhydration) and H2S

2015
The past decade has witnessed the discovery of hydrogen sulfide (H2S) as a new signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure, immunomodulator or anti-apoptotic agent, together with its great pharmacological potential, is now well established.
openaire   +2 more sources