Results 21 to 30 of about 1,081 (154)

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases. [PDF]

Microbiol Immunol
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.   +4 more
europepmc   +2 more sources

Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

Antioxidants, 2022
Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells.
Kelly Ascenção, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, Csaba Szabo   +5 more
doaj   +1 more source

Full-Length Transcriptome Comparison Provides Novel Insights into the Molecular Basis of Adaptation to Different Ecological Niches of the Deep-Sea Hydrothermal Vent in Alvinocaridid Shrimps

Diversity, 2022
The deep-sea hydrothermal vent ecosystem is one of the extreme chemoautotrophic environments. Shinkaicaris leurokolos Kikuchi and Hashimoto, 2000, and Alvinocaris longirostris Kikuchi and Ohta, 1995, are typically co-distributed and closely related ...
Aiyang Wang, Zhongli Sha, Min Hui
doaj   +1 more source

Synechococcus sp. Strain PCC7002 Uses Sulfide:Quinone Oxidoreductase To Detoxify Exogenous Sulfide and To Convert Endogenous Sulfide to Cellular Sulfane Sulfur

mBio, 2020
Eutrophication and deoxygenation possibly occur in coastal waters due to excessive nutrients from agricultural and aquacultural activities, leading to sulfide accumulation.
Daixi Liu, Jiajie Zhang, Chuanjuan Lü, Yongzhen Xia, Huaiwei Liu, Nianzhi Jiao, Luying Xun, Jihua Liu   +7 more
doaj   +1 more source

Selection on standing genetic variation mediates convergent evolution in extremophile fish

Molecular Ecology, Volume 32, Issue 18, Page 5042-5054, September 2023., 2023
Abstract Hydrogen sulfide is a toxic gas that disrupts numerous biological processes, including energy production in the mitochondria, yet fish in the Poecilia mexicana species complex have independently evolved sulfide tolerance several times. Despite clear evidence for convergence at the phenotypic level in these fishes, it is unclear if the repeated
Kara Ryan, Ryan Greenway, Jake Landers, Lenin Arias‐Rodriguez, Michael Tobler, Joanna L. Kelley   +5 more
wiley   +1 more source

Sulfane sulfur‐activated actinorhodin production and sporulation is maintained by a natural gene circuit in Streptomyces coelicolor

Microbial Biotechnology, 2020
Summary Sulfane sulfur, including polysulfide and persulfide, is a newly identified cellular component present in microorganisms; however, its physiological functions are unclear.
Ting Lu, Qun Cao, Xiuhua Pang, Yongzhen Xia, Luying Xun, Huaiwei Liu   +5 more
doaj   +1 more source

Stimulus-responsive proteins involved in multi-process regulation of storage substance accumulation during rice grain filling under elevated temperature

BMC Plant Biology, 2023
Background The intensified global warming during grain filling deteriorated rice quality, in particular increasing the frequency of chalky grains which markedly impact market value.
Yufei Zhao, Tongyang Yin, Xuan Ran, Wenzhe Liu, Yingying Shen, Hao Guo, Yuxuan Peng, Chen Zhang, Yanfeng Ding, She Tang   +9 more
doaj   +1 more source

A highly active S1‐P1 nuclease from the opportunistic pathogen Stenotrophomonas maltophilia cleaves c‐di‐GMP

FEBS Letters, Volume 597, Issue 16, Page 2103-2118, August 2023., 2023
The newly characterized nuclease SmNuc1 from the bacterium Stenotrophomonas maltophilia, a human opportunistic pathogen, shows an unusually high level of activity towards RNA and DNA, but at the same time, it very efficiently cleaves cyclic diguanylate, the ubiquitous second messenger molecule of bacteria that is normally involved in signalling and ...
Blanka Husťáková, Mária Trundová, Kristýna Adámková, Tomáš Kovaľ, Jarmila Dušková, Jan Dohnálek   +5 more
wiley   +1 more source

Bidirectionally Regulating Viral and Cellular Ferroptosis with Metastable Iron Sulfide Against Influenza Virus

Advanced Science, Volume 10, Issue 17, June 13, 2023., 2023
mFeS induces the viral ferroptosis by enhancing the lipid peroxidation level, which results in a failed viral infection. In addition, Dc(mFeS) suppresses the cellular ferroptosis‐dependent intracellular replication of influenza virus via restoring influenza virus‐induced imbalance of sulfur metabolism, and the supply of intracellular S0 ...
Xinyu Miao, Yinyan Yin, Yulian Chen, Wenhui Bi, Yuncong Yin, Sujuan Chen, Daxin Peng, Lizeng Gao, Tao Qin, Xiufan Liu   +9 more
wiley   +1 more source

The Role of Persulfide Metabolism During Arabidopsis Seed Development Under Light and Dark Conditions

Frontiers in Plant Science, 2018
The sulfur dioxygenase ETHE1 oxidizes persulfides in the mitochondrial matrix and is involved in the degradation of L-cysteine and hydrogen sulfide. ETHE1 has an essential but as yet undefined function in early embryo development of Arabidopsis thaliana.
Christin Lorenz, Saskia Brandt, Ljudmilla Borisjuk, Hardy Rolletschek, Nicolas Heinzel, Takayuki Tohge, Alisdair R. Fernie, Hans-Peter Braun, Tatjana M. Hildebrandt   +8 more
doaj   +1 more source