Results 11 to 20 of about 27,046 (149)

Mechanism of Intracellular Elemental Sulfur Oxidation in Beggiatoa leptomitoformis, Where Persulfide Dioxygenase Plays a Key Role. [PDF]

Int J Mol Sci
Representatives of the colorless sulfur bacteria of the genus Beggiatoa use reduced sulfur compounds in the processes of lithotrophic growth, which is accompanied by the storage of intracellular sulfur. However, it is still unknown how the transformation of intracellular sulfur occurs in Beggiatoa representatives.
Rudenko TS, Trubitsina LI, Terentyev VV, Trubitsin IV, Borshchevskiy VI, Tishchenko SV, Gabdulkhakov AG, Leontievsky AA, Grabovich MY.   +8 more
europepmc   +5 more sources

The Role of Persulfide Metabolism During Arabidopsis Seed Development Under Light and Dark Conditions [PDF]

Frontiers in Plant Science, 2018
The sulfur dioxygenase ETHE1 oxidizes persulfides in the mitochondrial matrix and is involved in the degradation of L-cysteine and hydrogen sulfide. ETHE1 has an essential but as yet undefined function in early embryo development of Arabidopsis thaliana.
Christin Lorenz, Saskia Brandt, Ljudmilla Borisjuk, Hardy Rolletschek, Nicolas Heinzel, Takayuki Tohge, Alisdair R. Fernie, Hans-Peter Braun, Tatjana M. Hildebrandt   +8 more
doaj   +4 more sources

Structure and function of persulfide dioxygenase from <i>Pseudomonas aeruginosa</i>: Implications on H₂S homeostasis and interplay with nitric oxide. [PDF]

iScience
Hydrogen sulfide is an important signaling molecule, beneficial at physiological concentrations but harmful at higher levels, due to which a tight control of its bioavailability is essential. Here, we investigated persulfide dioxygenase, an enzyme involved in H2S catabolism, from the pathogen Pseudomonas aeruginosa (PaPDO). Deletion of the gene pdo led
Giordano F, Troilo F, Nastasi MR, Caruso L, Mellini M, Travaglini-Allocatelli C, Giardina G, Vicente JB, Rampioni G, Di Matteo A, Forte E, Giuffrè A.   +11 more
europepmc   +5 more sources

Causal links between iron status, mitochondrial function, and laryngeal and hypopharyngeal cancers: a Mendelian study [PDF]

Discover Oncology
Background This Mendelian randomization (MR) study aimed to investigate bidirectional causal relationships between genetically predicted iron homeostasis, mitochondrial function, and the risk of laryngeal and hypopharyngeal cancers. Methods Summary-level
Jiandong Zhao, Liwei Chen, Bing Han, Siyang Li, Yongxia Zhang, Ge Gao, Jinjing Liu   +6 more
doaj   +3 more sources

Human mitochondrial persulfide dioxygenase is potently and reversibly inhibited by nitric oxide

Biochimie
Hydrogen sulfide (H2S) regulates multiple human physiological processes, its reactivity and range of action being tightly controlled through regulation of H2S-synthesizing and -detoxifying enzymes. H2S detoxification is mainly achieved by a mitochondrial sulfide detoxifying pathway including persulfide dioxygenase (PDO).
Francesca Giordano, Elena Forte, Alessandro Giuffre   +2 more
exaly   +4 more sources

Ethylmalonic encephalopathy caused by biallelic truncating variants in ETHE1: A case report [PDF]

SAGE Open Medical Case Reports
Ethylmalonic encephalopathy is a rare autosomal recessive mitochondrial disorder caused by biallelic pathogenic variants in ETHE1 , the gene encoding mitochondrial persulfide dioxygenase, an enzyme crucial for hydrogen sulfide (H 2 S) detoxification ...
Delmer-Alejandro Ruiz-Martinez, Emilio-Rodrigo Vega-Peniche, Yazmin Quiñonez-Pacheco, Hugo Laviada-Molina, Carlos-Alejandro Medina-Campos, Felix-Julian Campos-Garcia   +5 more
doaj   +3 more sources

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

mBio, 2020
Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A.
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc   +7 more
doaj   +2 more sources

Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria

Redox Biology, 2022
Heterotrophic bacteria and human mitochondria often use sulfide: quinone oxidoreductase (SQR) and persulfide dioxygenase (PDO) to oxidize sulfide to sulfite and thiosulfate.
Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun, Yongzhen Xia   +7 more
doaj   +2 more sources

HIF-1 Has a Central Role in Caenorhabditis elegans Organismal Response to Selenium

Frontiers in Genetics, 2020
Selenium is a trace element for most organisms; its deficiency and excess are detrimental. Selenium beneficial effects are mainly due to the role of the 21st genetically encoded amino acid selenocysteine (Sec).
Laura Romanelli-Credrez, Maria Doitsidou, Mark J. Alkema, Gustavo Salinas   +3 more
doaj   +3 more sources

Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids

Antioxidants, 2022
Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells.
Kelly Ascenção, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, Csaba Szabo   +5 more
doaj   +2 more sources