Results 51 to 60 of about 14,681 (257)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
TEMPS, TRADUCTION ET THÉORIE DE LA PERTINENCE
Studia Universitatis Moldaviae: Stiinte Umanistice, 2019 Nous nous proposons de dresser une synthèse des postulats de la Théorie de la pertinence, élaborée par Dan Sperber et Deirdre Wilson, dans le contexte des problèmes posés par le transfert des contenus temporels lors de la traduction du français en ...
USM ADMIN
doaj +2 more sources
Les normes dans leur diversité. Quelle pertinence ? [PDF]
Echo des Etudes Romanes, 2015 The concept of norm is particularly ambiguous in French. It can refer to official, objective, subjective, regional, popular standards, etc. Therefore the objective of this paper is to determine if these different standards have almost the same status
Feuillard Colette
doaj
The dynamics of semiotics of culture; its pertinence to anthropology
Sign Systems Studies, 1999 The dynamics of semiotics of culture; its pertinence to ...
Irene Portis-Winner
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Lien Social et Politiques, 2009 Cet article propose d’analyser et de comparer deux stratégies globales de lutte contre la pauvreté et l’exclusion sociale mises en oeuvre au Canada, soit celles du Québec et de Terre-Neuve-et-Labrador. La démarche s’inspire de la théorie du policy design
Matthieu Mondou
doaj +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source