Results 61 to 70 of about 64,492 (258)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Cost objective PLM and CE [PDF]
Concurrent engineering taking into account product life-cycle factors seems to be one of the industrial challenges of the next years. Cost estimation and management are two main strategic tasks that imply the possibility of managing costs at the earliest
Alain Bernard, Nicolas Perry
core
Lien Social et Politiques, 2009 Cet article propose d’analyser et de comparer deux stratégies globales de lutte contre la pauvreté et l’exclusion sociale mises en oeuvre au Canada, soit celles du Québec et de Terre-Neuve-et-Labrador. La démarche s’inspire de la théorie du policy design
Matthieu Mondou
doaj +1 more source
Application of WeChat public platform in standardized training of surgical residents [PDF]
Jichu yixue yu linchuang, 2020 As a popular media sharing platform in recent years, WeChat public platform has great potential in education. This paper takes the public number “PUMC training and teaching” as an example to explore the application of WeChat public platform in ...
XIAO Jian-chun, ZHANG Miao-yan, XU Yuan, WU Bin
doaj
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Loyers de référence : amplitude et pertinence
, 2003 Pain Bernard. Loyers de référence : amplitude et pertinence. In: Droit et Ville, tome 55, 2003. Journée d'étude : Le renouvellement urbain (Toulouse, 18 octobre 2002) - Colloque : L’évolution jurisprudentielle en matière de baux commerciaux (Toulouse, 31
Pain, Bernard
core +1 more source
TEMPS, TRADUCTION ET THÉORIE DE LA PERTINENCE
Studia Universitatis Moldaviae: Stiinte Umanistice, 2019 Nous nous proposons de dresser une synthèse des postulats de la Théorie de la pertinence, élaborée par Dan Sperber et Deirdre Wilson, dans le contexte des problèmes posés par le transfert des contenus temporels lors de la traduction du français en ...
USM ADMIN
doaj +2 more sources
Nighttime Pedestrian Ranging Algorithm Based on Monocular Vision
Cybernetics and Information Technologies, 2016 Since the traditional computer vision ranging algorithm is imperfect in pertinence and precision, night time monocular vision pedestrian ranging method is proposed for vehicular infrared night vision goggles.
Wang Hongxia, Kang Xue-Xue, Yu Yang
doaj +1 more source
Journal of Medical Education and Curricular Development, 2020 The traditional, subject-based medical curriculum in Colombia has been mainly focused on the biomedical model proposed by Flexner in 1910. This means learning outcomes or competences are framed on curative care and the specialization of physicians ...
Gustavo-Adolfo Quintero +3 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source