Results 91 to 100 of about 747,493 (287)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Nontrivial Solution for the Fractional p-Laplacian Equations via Perturbation Methods

Advances in Mathematical Physics, 2017
We study the existence of nontrivial solution of the following equation without compactness: (-Δ)pαu+up-2u=f(x,u),  x∈RN, where N,p≥2,  α∈(0,1),  (-Δ)pα is the fractional p-Laplacian, and the subcritical p-superlinear term f∈C(RN×R) is 1-periodic in xi ...
Huxiao Luo, Shengjun Li, Xianhua Tang
doaj   +1 more source

Development of an Adjoint Flux Calculation Technique for Exact Perturbation Theory in Monte Carlo Code MCS [PDF]

EPJ Web of Conferences
A calculation technique computing the adjoint flux of perturbed system is developed for the exact perturbation theory in Monte Carlo transport. By using a correlated sampling and iterated fission probability methods together, the adjoint flux of ...
Jo Yunki, Lee Deokjung
doaj   +1 more source

Rational Homotopy Perturbation Method [PDF]

Journal of Applied Mathematics, 2012
The solution methods of nonlinear differential equations are very important because most of the physical phenomena are modelled by using such kind of equations. Therefore, this work presents a rational version of homotopy perturbation method (RHPM) as a novel tool with high potential to find approximate solutions for nonlinear differential equations ...
openaire   +3 more sources

Integrability and Wilson loops: the wavy line contour

, 2013
The Wilson loop with a wavy line contour is studied using integrable methods. The auxiliary problem is solved and the Lax operator is built to first order in perturbation theory, considering a small perturbation from the straight line.
Cagnazzo, A.
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Dynamical Structures Associated with High-Order and Secondary Resonances in the Spin–Orbit Problem

The Astronomical Journal
In our solar system, spin–orbit resonances are common under Sun–planet, planet–satellite, and binary asteroid configurations. In this work, high-order and secondary spin–orbit resonances are investigated by taking numerical and analytical approaches ...
Hanlun Lei
doaj   +1 more source

Perturbation Methods for the Eigencharacteristics of Symmetric and Asymmetric Systems

Shock and Vibration, 2018
Dynamic analysis for a vibratory system typically begins with an evaluation of its eigencharacteristics. However, when design changes are introduced, the eigensolutions of the system change and thus must be recomputed.
Philip D. Cha, Austin Shin
doaj   +1 more source