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Acellular Pertussis Vaccine Inhibits Bordetella pertussis Clearance from the Nasal Mucosa of Mice [PDF]

open access: yesVaccines, 2020
Bordetella pertussis whole-cell vaccines (wP) caused a spectacular drop of global pertussis incidence, but since the replacement of wP with acellular pertussis vaccines (aP), pertussis has resurged in developed countries within 7 to 12 years of the ...
Jana Holubová   +7 more
doaj   +3 more sources

Whole-Cell and Acellular Pertussis Vaccine: Reflections on Efficacy [PDF]

open access: yesMed Princ Pract, 2022
Pertussis is a common respiratory infection caused by the bacterium Bordetella pertussis. Although most cases occur in developing countries, it is considered endemic globally.
Mohammad Alghounaim   +4 more
semanticscholar   +2 more sources

Pertactin-Deficient Bordetella pertussis, Vaccine-Driven Evolution, and Reemergence of Pertussis [PDF]

open access: yesEmerg Infect Dis, 2021
Recent reemergence of pertussis (whooping cough) in highly vaccinated populations and rapid expansion of Bordetella pertussis strains lacking pertactin (PRN), a common acellular vaccine antigen, have raised the specter of vaccine-driven evolution and ...
Longhuan Ma   +3 more
semanticscholar   +2 more sources

A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains

open access: yesFrontiers in Cellular and Infection Microbiology, 2019
Pertussis is a respiratory infectious disease that has been resurged during the last decades. The change from the traditional multi-antigen whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines that consist of a few antigens formulated ...
María Eugenia Zurita   +7 more
doaj   +2 more sources

Recommendation for the use of newly introduced Tdap vaccine in Korea [PDF]

open access: yesKorean Journal of Pediatrics, 2011
Pertussis is an acute respiratory infection characterized by paroxysmal cough and inspiratory whoop for over 2 weeks. The incidence of pertussis has decreased markedly after the introduction of DTwP/DTaP vaccine, but the incidence of pertussis has ...
Kyong Min Choi   +9 more
doaj   +5 more sources

A novel vaccine formulation candidate based on lipooligosaccharides and pertussis toxin against Bordetella pertussis

open access: yesFrontiers in Immunology, 2023
Pertussis is a severe human respiratory tract infectious disease caused by Bordetella pertussis that primarily affects infants and young children.
Jingjing Gao   +6 more
doaj   +1 more source

Comparing the pertussis antibody levels of healthy children immunized with four doses of DTap-IPV/Hib (Pentaxim) combination vaccine and DTaP vaccine in Quzhou, China

open access: yesFrontiers in Immunology, 2023
Despite the high coverage of pertussis vaccines in high-income countries, pertussis resurgence has been reported in recent years, and has stimulated interest in the effects of vaccines and vaccination strategies. Immunoglobulin G (IgG) antibodies against
Zhiying Yin   +8 more
doaj   +1 more source

Seroprevalence of Antibodies to Pertussis Toxin among Different Age Groups in Thailand after 37 Years of Universal Whole-Cell Pertussis Vaccination. [PDF]

open access: yesPLoS ONE, 2016
Despite the high coverage of prophylactic vaccine against Bordetella pertussis infection in many countries for more than three decades, pertussis remains a common vaccine-preventable disease. Infections have been detected more commonly in countries using
Nasamon Wanlapakorn   +5 more
doaj   +1 more source

Pertussis vaccines and the role of Bordetella pertussis lipooligosaccharide in the immune response to pertussis infection and vaccination

open access: yesБиопрепараты: Профилактика, диагностика, лечение, 2021
Some scientific publications contain data suggesting the “return” or “resurgence” of pertussis. Prevention and elimination of pertussis can only be achieved by extensive immunisation of susceptible populations with a highly effective vaccine.
I. A. Alekseeva   +2 more
doaj   +1 more source

Chemical Synthesis and Immunological Evaluation of Pertussis-Like Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine.

open access: yesAngewandte Chemie, 2020
The 60-year high Bordetella pertussis ( B. pertussis ) infection rate in the world suggests the urgent need for new anti-pertussis vaccines. Lipopolysaccharide (LPS) of B. pertussis is an attractive antigen for vaccine development.
Peng Wang   +7 more
semanticscholar   +1 more source

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