Results 31 to 40 of about 636,928 (222)

Non-specific Effects of Live Attenuated Pertussis Vaccine Against Heterologous Infectious and Inflammatory Diseases

Frontiers in Immunology, 2018
Bordetella pertussis is the agent of pertussis, also referred to as whooping cough, a disease that remains an important public health issue. Vaccine-induced immunity to pertussis wanes over time. In industrialized countries, high vaccine coverage has not
S. Cauchi, C. Locht
semanticscholar   +1 more source

Live Attenuated Pertussis Vaccine BPZE1 Protects Baboons Against Bordetella pertussis Disease and Infection

Journal of Infectious Diseases, 2017
Summary The resurgence of pertussis may originate from inefficient vaccine-mediated protection against infection by Bordetella pertussis. Here, we show that the live attenuated vaccine BPZE1 is safe in nonhuman primates and induces robust protection ...
C. Locht, James F. Papin, Sophie Lecher, A. Debrie, M. Thalen, K. Solovay, Keith Rubin, N. Mielcarek   +7 more
semanticscholar   +1 more source

Pertussis Toxin: A Key Component in Pertussis Vaccines?

Toxins, 2019
B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The ongoing resurgence in pertussis incidence in high income countries is likely due to faster waning of immunity and increased asymptomatic colonization in individuals ...
Kelsey A. Gregg, Tod J. Merkel
doaj   +1 more source

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999–2015

Journal of the Pediatric Infectious Diseases Society, 2018
Background Recent increases in pertussis morbidity and mortality rates among young infants have led to a recommendation in some countries for vaccination against pertussis during pregnancy.
B. Abu-Raya, J. Bettinger, O. Vanderkooi, W. Vaudry, S. Halperin, M. Sadarangani, N R K S P R D M A M N D L S J B B A T R O J W D J M Bridger Morris Top Halperin Déry Thibeault Moore ., N. Bridger, R. Morris, K. Top, S. Halperin, P. Déry, R. Thibeault, D. Moore, M. Lefebvre, M. Lebel, N. Le Saux, D. Tran, L. Ford-jones, S. Morris, J. Embree, B. Law, B. Tan, A. McConnell, T. Jadavji, R. Chawla, O. Vanderkooi, J. Kellner, W. Vaudry, D. Scheifele, J. Bettinger, M. Sadarangani, L. Sauvé   +32 more
semanticscholar   +1 more source

A novel method for the extraction of outer membrane vesicles (OMVs) from Bordetella pertussis Tohama strain

Iranian Journal of Microbiology, 2020
Background and Objectives: There are many pertussis outbreaks which is mainly due to the reduction in the immunity of acellular pertussis (aP) vaccines. Therefore, there is a crucial necessity to develop a new generation of pertussis vaccine.
Mohammad Sekhavati, Ashraf Mohabati Mobarez, Seyed Davar Siadat, Mojtaba Noofeli   +3 more
doaj   +1 more source

Evaluation of Whole-Cell and Acellular Pertussis Vaccines in the Context of Long-Term Herd Immunity

Vaccines, 2022
After the pertussis vaccine had been introduced in the 1940s and was shown to be very successful in reducing the morbidity and mortality associated with the disease, the possibility of improving both vaccine composition and vaccination schedules has ...
Ewa Szwejser-Zawislak, Mieszko M. Wilk, Piotr Piszczek, Justyna Krawczyk, Daria Wilczyńska, Daniela Hozbor   +5 more
doaj   +1 more source

No increased risk of spinal cerebrospinal fluid leak after spinal manipulative therapy: A retrospective cohort study

PM&R, EarlyView.
Abstract Background Spinal cerebrospinal fluid (CSF) leaks, a rare but debilitating condition, have been described following spinal manipulative therapy (SMT) in case reports. However, the nature of the potential association between SMT and CSF leak is uncertain, and symptoms such as neck pain or headache may reflect preexisting leaks rather than ...
Robert J. Trager, Collin M. Labak, Anthony N. Baumann, Tyler H. Snodgrass, Zachary A. Cupler   +4 more
wiley   +1 more source

A new socioeconomic status measure for vaccine research in children using individual housing data: a population-based case-control study

BMC Public Health, 2016
Background We recently developed HOUSES, an individual housing-based socioeconomic status (SES) measurement for health disparities research. We assessed whether HOUSES was associated with risk of pertussis and pertussis vaccine up-to-date status in ...
Rachel Hammer, Conrad Capili, Chung-Il Wi, Euijung Ryu, Jennifer Rand-Weaver, Young J. Juhn   +5 more
doaj   +1 more source

Effect of FHA and Prn on Bordetella pertussis colonization of mice is dependent on vaccine type and anatomical site.

PLoS ONE, 2020
Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10-20 years.
Anne Zeddeman, Evi van Schuppen, Kristianne E Kok, Marjolein van Gent, Kees J Heuvelman, Marieke J Bart, Han G J van der Heide, Joshua Gillard, Elles Simonetti, Marc J Eleveld, Fred J H van Opzeeland, Saskia van Selm, Ronald de Groot, Marien I de Jonge, Frits R Mooi, Dimitri A Diavatopoulos   +15 more
doaj   +1 more source

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source