Structural Diversity of Perylenequinones Is Driven by Their Redox Behavior [PDF]
Journal of Organic Chemistry, 2022 Hypocrellins and hypomycins are two sub-classes of fungal perylenequinones with unique structural, biological, and photochemical properties. With the growing interest in these naturally-occurring photosensitizers, more studies were warranted to better ...
Michael John Hall +2 more
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Screening of Anti-Inflammatory Activity and Metabolomics Analysis of Endophytic Fungal Extracts; Identification and Characterization of Perylenequinones and Terpenoids from the Interesting Active Alternaria Endophyte [PDF]
Molecules, 2023 Patients suffering from inflammatory chronic diseases are classically treated with anti-inflammatory drugs but unfortunately are highly susceptible to becoming resistant to their treatment.
François Dupire +2 more
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Structure elucidation and biological activities of perylenequinones from an Alternaria species [PDF]
Mycotoxin Research, 2023 The KEAP1-Nrf2/ARE pathway is a pivotal cytoprotective regulator against oxidative stress which plays an important role in the development of many inflammatory diseases and cancer.
Till Opatz +2 more
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Mycological Progress, 2022 Perylenequinones (PQs) are aromatic polyketides with an oxidized pentacyclic core that make up a family of natural compounds. Naturally occurring PQs mostly are produced by phytopathogenic fungi, with few aphides, crinoids, and plants. PQs, also known as
Afra Khiralla, Sakina Yagi
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Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa [PDF]
Heliyon, 2018 The differential solvent extraction and further purification of fractions of endophytic Alternaria sp. isolated from Pinus ponderosa led to the isolation of further two perylenequinone compounds as 3,6,6a,9,10-pentahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,
Mudasir A. Tantry +7 more
doaj +6 more sources
Nitric oxide regulates perylenequinones biosynthesis in Shiraia bambusicola S4201 induced by hydrogen peroxide [PDF]
Scientific Reports, 2021 Shiraia bambusicola has been used as a traditional Chinese medicine for a long history. Its major medicinal active metabolites are perylenequinones, including hypocrellin A, elsinochrome A and so on. At present, the fermentation yield of perylenequinones
Mingzhu Dou
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Enhanced Production and Anticancer Properties of Photoactivated Perylenequinones [PDF]
Journal of Natural Products, 2020 Hypocrellins and hypomycins are naturally occurring fungal perylenequinones with potential photodynamic activity against cancer and microbial diseases. This project pursued three lines of research.
Zeinab Al Subeh +2 more
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Perylenequinones: Isolation, Synthesis, and Biological Activity [PDF]
European Journal of Organic Chemistry, 2012 The perylenequinones are a novel class of natural products characterized by pentacyclic conjugated chromophore giving rise to photoactivity. Potentially useful light-activated biological activity, targeting protein kinase C (PKC), has been identified for
Marisa Kozlowski
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Scaling up the production of fungal perylenequinones and investigating their biosynthesis through stable isotope labeling [PDF]
Microbial Cell FactoriesBackground Perylenequinones, such as hypocrellins and hypomycins, are fungal secondary metabolites with potential for pharmaceutical and industrial applications due to both their physical and biological properties. This study focused on their sustainable
Reema A. Al-Qiam +7 more
doaj +3 more sources
Advances and perspectives on perylenequinone biosynthesis [PDF]
Frontiers in Microbiology, 2022 Under illumination, the fungal secondary metabolites, perylenequinones (PQs) react with molecular oxygen to generate reactive oxygen species (ROS), which, in excess can damage cellular macromolecules and trigger apoptosis.
Huaxiang Deng +6 more
doaj +4 more sources