Naturally Occurring Partially Reduced Perylenequinones from Fungi
Journal of Natural Products, 2022 This Review provides a critical analysis of the literature covering the naturally occurring partially reduced perylenequinones (PQs) from fungi without carbon substituents (which can be named class A perylenequinones) and discusses their structures ...
Regina Geris, Thomas Simpson
exaly +5 more sources
Volatiles of Shiraia fruiting body-associated Pseudomonas putida No.24 stimulate fungal hypocrellin production [PDF]
Synthetic and Systems Biotechnology, 2023 Hypocrellins are major bioactive perylenequinones from Shiraia fruiting bodies and have been developed as efficient photosensitizers for photodynamic therapy.
Rui Xu +5 more
doaj +3 more sources
E3S Web of Conferences, 2019 The perylenequinones derivatives (PQDs) are potential photosensitizers, which have a high effective light-induced biological activity, such as anti-HIV, antimicrobial and anticancer activities.
Zhang Yuejie +2 more
doaj +4 more sources
The interplay of configuration and conformation in helical perylenequinones: Insights from chirality induction in liquid crystals and calculations [PDF]
Beilstein Journal of Organic Chemistry, 2012 The chirality transfer in liquid crystals induced by two helical perylenequinones (namely, the natural compounds cercosporin and phleichrome) was investigated by integrating measurements of helical twisting power with a conformational analysis by DFT ...
Elisa Frezza +4 more
doaj +3 more sources
Redox Homeostasis as a Key Regulator of Intramolecular Cyclization in Fungal Perylenequinones. [PDF]
ACS Chem BiolPerylenequinones (PQs) such as hypocrellins and hypomycins are fungal-derived redox-active metabolites with known roles as photosensitizers in the oxidative stress response and applications in photodynamic therapy (PDT). Here, we report that Shiraia sp.,
Al-Qiam RA +6 more
europepmc +4 more sources
Production of the light-activated elsinochrome phytotoxin in the soybean pathogen Coniothyrium glycines hints at virulence factor. [PDF]
PLoS ONEThe Dothideomycete pathogen Coniothyrium glycines causes red leaf blotch of soybean, a major disease in Africa. It is one of two fungal plant pathogens on the USDA PPQ Select Agents and Toxins list of pathogens important to the biosecurity of the United ...
Nicholas Greatens +8 more
doaj +5 more sources
Chemical Diversity and Biological Activities of Phaeosphaeria Fungi Genus: A Systematic Review [PDF]
Journal of Fungi, 2018 Microbial natural products (MNPs) have been identified as important hotspots and effective sources for drug lead discovery. The genus Phaeosphaeria (family: Phaeosphaeriaceae, order: Pleosporales), in particular, has produced divergent chemical ...
Amr El-Demerdash
doaj +3 more sources
Effects of branched-chain amino acids on Shiraia perylenequinone production in mycelium cultures [PDF]
Microbial Cell Factories, 2023 Background Perylenequinones from Shiraia fruiting bodies are excellent photosensitizers and widely used for anti-cancer photodynamic therapy (PDT). The lower yield of Shiraia perylenequinones becomes a significant bottleneck for their medical application.
Wen Hao Shen +5 more
doaj +2 more sources
Natural Perylenequinone Compounds as Potent Inhibitors of Schistosoma mansoni Glutathione S-Transferase [PDF]
Life, 2023 The existing treatment strategy for Schistosomiasis centers on praziquantel, a single drug, but its effectiveness is limited due to resistance and lack of preventive benefits. Thus, there is an urgent need for novel antischistosomal agents.
Benson Otarigho, Mofolusho O. Falade
doaj +2 more sources
Phylogenetic Position of Shiraia-Like Endophytes on Bamboos and the Diverse Biosynthesis of Hypocrellin and Hypocrellin Derivatives [PDF]
Journal of Fungi, 2021 The main active ingredients of the fruiting bodies of Shiraia bambusicola and Rubroshiraia bambusae are Hypocrellins, belonging perylenequinones with potential photodynamic activity against cancer and microbial diseases.
Xin Tong +4 more
doaj +2 more sources