Production of fungal hypocrellin photosensitizers: Exploiting bambusicolous fungi and elicitation strategies in mycelium cultures [PDF]
MycologyHypocrellins, a group of naturally occurring perylenequinone pigments produced by Shiraia bambusicola, are notable for their potential use in photodynamic therapy (PDT) for treating cancers and viruses.
Xin Ping Li +3 more
doaj +2 more sources
Contrasting regulation of live Bacillus cereus No.1 and its volatiles on Shiraia perylenequinone production [PDF]
Microbial Cell Factories, 2022 Background Fungal perylenequinones (PQs) are a class of photoactivated polyketide mycotoxins produced by plant-associated fungi. Hypocrellins, the effective anticancer photodynamic therapy (PDT) agents are main bioactive PQs isolated from a bambusicolous
Rui Xu +5 more
doaj +2 more sources
Elsinochrome A photosensitizers: Alternative drugs for photodynamic therapy [PDF]
Journal of Innovative Optical Health Sciences, 2015 Photodynamic therapy (PDT) has already been a multifunctional modality for various tumors and nontumorous diseases. However, the development of photosensitizers is relatively delayed, compared with the tremendous progress in laser technology ...
Tinghui Li +3 more
doaj +2 more sources
Fruiting body-associated Pseudomonas contact triggers ROS-mediated perylenequinone biosynthesis in Shiraia mycelium culture [PDF]
Bioresources and BioprocessingPerylenequinones (PQs) from Shiraia fruiting bodies serve as potent photosensitizers for anticancer and antimicrobial photodynamic therapy (PDT). Although these fruiting bodies harbor diverse endophytic bacteria, their interactions with the host fungus ...
Yan Jun Ma +4 more
doaj +2 more sources
Nitric oxide mediates red light-induced perylenequinone production in Shiraia mycelium culture [PDF]
Bioresources and BioprocessingPerylenequinones (PQs) from bambusicolous Shiraia fungi serve as excellent photosensitizers for photodynamic therapy. However, the lower yield of PQ production in mycelium cultures is an important bottleneck for their clinical application. Light has long
Wen Juan Wang +6 more
doaj +2 more sources
Transcriptome analysis on fructose as the sole carbon source enhancing perylenequinones production of endophytic fungus Shiraia sp. Slf14. [PDF]
3 Biotech, 2020 Liu Z +5 more
europepmc +2 more sources
Natural Photosensitizers in Cancer Therapy: A Chemo-Biodiversity Perspective on Light-Activated Natural Compounds. [PDF]
Chem BiodiversNatural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Baidoo I, Abrahamse H, George BP.
europepmc +2 more sources
Structural Diversity of Perylenequinones is Driven by their Redox Behavior [PDF]
Hypocrellins and hypomycins are two sub-classes of fungal perylenequinones with unique phototoxic properties. Of these, more is known about hypocrellins, which were reported to have phototoxic activity against a variety of cancer cell lines and microbes;
Pearce CJ +8 more
core +4 more sources
Journal of Natural Products, 2021 A new axial chiral binaphtoquinone, hypocrellone (1), and a new perylenequinone, hypomycin F (2), were isolated from the stromata of Hypocrella bambusae, together with five known compounds, 3-7.
Yu-Ting Li +9 more
semanticscholar +1 more source
Multiple paths of plant host toxicity are associated with the fungal toxin cercosporin
Plant, Cell &Environment, Volume 46, Issue 8, Page 2542-2557, August 2023., 2023 Abstract The Cercospora species of fungi are responsible for leaf spot disease affecting many key economic crops. Most of these fungi secrete a toxic photodynamic molecule, cercosporin, that reacts with light and oxygen to produce reactive singlet oxygen (1O2) contributing to fungal virulence.
Eugene Koh +4 more
wiley +1 more source