Results 61 to 70 of about 1,328 (134)

Peucedanum praeruptorum Dunn

, 2019
<i>2.1. Identification of the cDNA encoding PAL in P. praeruptorum</i> <p> Using PAL sequences reported previously and our transcriptome database of <i>P. praeruptorum</i> (accession no.
Luo, Jun, Zhao, Yucheng, Sui, Ziwei, Huang, Chuanlong, Kong, Lingyi, Yao, Ruolan   +5 more
core   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Qianhu (Peucedanum praeruptorum Dunn) Improves exercise capacity in mice by regulating Nrf2/HO-1 oxidative stress signaling pathway

Applied Biological Chemistry, 2023
This study assessed the effect of Qianhu (Peucedanum praeruptorum Dunn) on the recovery of movement in mice with D-galactose-induced dyskinesia. The evaluation of the ability of mice to exercise revealed that Qianhu increased the running and swimming ...
Bo Li, Yeni Wang, Xiaoguang Yang
doaj   +1 more source

A Novel Neutral Polysaccharide From Bamboo Shoot Processing Liquid: Structural Characterization and In Vitro TLR4/NF‐κB Mediated Anti‐Inflammatory Activity

Food Bioengineering, Volume 5, Issue 1, Page 73-87, March 2026.
ABSTRACT Value‐added utilization of resources can be developed from by‐products of agricultural processing. In this study, a neutral polysaccharide (BSLP‐1, 19,799 Da) was obtained from bamboo shoot processing liquid. Structurally, BSLP‐1 has a backbone of →4)‐α‐D‐Glcp‐(1→ and →4,6)‐α‐D‐Glcp‐(1→, with side chains of →5)‐α‐L‐Araf‐(1→ and α‐D‐Glcp‐(1→6 ...
Shouzhen Li, Jinglu Jiang, Ken Cheng, Ahsan Hafiz Muhammad, Tingting Bu, Huimin Yang, Xuelan Cao, Wen Xiang, Peilong Sun, Ming Cai   +9 more
wiley   +1 more source

Pra-C exerts analgesic effect through inhibiting microglial activation in anterior cingulate cortex in complete Freund’s adjuvant-induced mouse model

Molecular Pain, 2021
Chronic pain is highly prevalent worldwide and severely affects daily lives of patients and family members. Praeruptorin C (Pra-C) is a main active ingredient derived from Peucedanum praeruptorum Dunn, traditionally used as antibechic, anti-bronchitis ...
Dan-jie Su, Long-fei Li, Sai-ying Wang, Qi Yang, Yu-jing Wu, Ming-gao Zhao, Le Yang   +6 more
doaj   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, Volume 45, Issue 6, Page 1850-1882, November 2025.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds

Aging Cell, Volume 24, Issue 8, August 2025.
ElixirSeeker is a machine learning architecture based on a phenotype‐driven drug discovery approach to screen lifespan‐extending compounds. By integrating molecular fingerprints, ElixirSeeker could maximize feature capture of lifespan‐extending compounds.
Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, Jing Yang, Junyu Ning, Bo Xian   +15 more
wiley   +1 more source

Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In Vitro and In Vivo Insights

Pharmacology Research &Perspectives, Volume 13, Issue 2, April 2025.
Cordycepin from Cordyceps sinensis has shown certain neuroprotective effects and alleviated the formation of mHTT aggregates in different HD cell and transgenic mouse models. ABSTRACT Huntington's disease (HD) is a challenging neurodegenerative disorder linked to Huntingtin (HTT) gene mutation, lacking an effective cure despite numerous therapeutic ...
Chih‐Wei Tung, Siew Chin Chan, Pei‐Hsun Cheng, Yi‐Ching Chen, Po‐Ming Wu, Wei‐Chen Lin, Rong‐Jane Chen, Bu‐Miin Huang, Shang‐Hsun Yang   +8 more
wiley   +1 more source

Genome sequencing of three Polyscias species reveals common features in terpene synthase gene family evolution in these species

The Plant Genome, Volume 18, Issue 1, March 2025.
Abstract The genus Polyscias, part of the Araliaceae family, is known for its significant ornamental and medicinal value, as well as its rich variety of metabolites. These plants are primarily found in tropical regions, particularly in Southeast Asia and the Pacific islands. The diverse geographical environments have led to the emergence of many unique
Mingzhou Bai, Xin Yang, David H. Lorence, Kenneth R. Wood, Natalie Iwanycki Ahlstrand, Timothy W. Flynn, Shancen Zhao, Nina Rønsted, Henrik Toft Simonsen   +8 more
wiley   +1 more source

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption

Frontiers in Pharmacology, 2017
Being a highly prevalent disease, osteoporosis causes metabolism defects. Low bone density, compromised bone strength, and an increased danger of fragility fracture are its main characteristics.
Xuqiang Liu, Jie-Fen Chin, Xinhua Qu, Haidi Bi, Yuan Liu, Ziqiang Yu, Zanjing Zhai, An Qin, Bin Zhang, Min Dai   +9 more
doaj   +1 more source