Results 211 to 220 of about 4,673 (237)
Wide variation in microsatellite sequences within each Pfcrt mutant haplotype
Molecular and Biochemical Parasitology, 2006 Flanking microsatellites for each of the Pfcrt mutant haplotype of Plasmodium falciparum remain conserved among geographical isolates. We describe here heterogeneity in the intragenic microsatellites among each of the Pfcrt haplotype. There were fourteen
Sumiti Vinayak, Yagya D Sharma
exaly +4 more sources
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance [PDF]
EMBO Journal, 2005 Chloroquine resistance (CQR) in Plasmodium falciparum is associated with mutations in the digestive vacuole transmembrane protein PfCRT. However, the contribution of individual pfcrt mutations has not been clarified and other genes have been postulated ...
David Fidock +2 more
exaly +4 more sources
First evidence of pfcrt mutant Plasmodium falciparum in Madagascar [PDF]
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2006 The island of Madagascar, lying in the Indian Ocean approximately 250 miles from the African coast, has so far remained one of the few areas in the world without noticeable Plasmodium falciparum high-grade chloroquine (CQ) resistance. Here we report genotyping data on pfcrt in Madagascar. The pfcrt K76T mutation, which is critical for resistance to CQ,
David Fidock +2 more
exaly +3 more sources
Combinatorial Genetic Modeling ofpfcrt-Mediated Drug Resistance Evolution inPlasmodium falciparum
Molecular Biology and Evolution, 2016 International audienceThe emergence of drug resistance continuously threatens global control of infectious diseases, including malaria caused by the protozoan parasite Plasmodium falciparum. A critical parasite determinant is the P.
David Fidock +2 more
exaly +2 more sources
Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes [PDF]
Journal of Biological Chemistry, 2017 The chloroquine resistance transporter of the human malaria parasite Plasmodium falciparum, PfCRT, is an important determinant of resistance to several quinoline and quinoline-like antimalarial drugs. PfCRT also plays an essential role in the physiology of the parasite during development inside erythrocytes.
Michael Lanzer +2 more
exaly +3 more sources
Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum [PDF]
Journal of Biological Chemistry, 2019 International audienceThe chloroquine resistance transporter PfCRT of the human malaria parasite Plasmodium falciparum confers resistance to the former first-line antimalarial drug chloroquine, and it modulates the responsiveness to a wide range of ...
Daniel Ayoub +2 more
exaly +2 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Pfcrt haplotypes and in-vivo chloroquine response in Sundergarh district, Orissa, India
Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007The Plasmodium falciparum chloroquine resistance transporter (Pfcrt) K76T mutation and haplotype (amino acids 72-76) were analyzed as markers of chloroquine (CQ) resistance in the blood samples of patients from two sites of different intensities of malaria transmission (high, n=70; low, n=68) in Sundergarh district of Orissa, India and correlated with ...
Praveen Kishore Sahu +2 more
exaly +3 more sources
A Novel Transporter, Pfcrt, Confers Antimalarial Drug Resistance
Journal of Membrane Biology, 2002The elucidation of the molecular details of drug resistance phenomena is a very active area of research that crosses many disciplinary boundaries. Drug resistance is due to altered drug-target interaction, and/or dysregulated signaling related to cell growth and death.
E M, Howard, H, Zhang, P D, Roepe
openaire +2 more sources
Molecular and Biochemical Parasitology, 2001
Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium falciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty ...
R, Durand +5 more
openaire +2 more sources
Recent transfection based studies demonstrated that cg2, a candidate gene for chloroquine resistance in Plasmodium falciparum, was not the resistance determinant. A further analysis of the initial 36 kb locus comprising the cg2 gene led to the discovery of another gene, pfcrt, which was absolutely associated with chloroquine resistance in forty ...
R, Durand +5 more
openaire +2 more sources
Trafficking of the Phosphoprotein PfCRT to the Digestive Vacuolar Membrane inPlasmodium falciparum
Traffic, 2010The digestive vacuole plays an important role in the pathophysiology of the human malaria parasite Plasmodium falciparum. It is a terminal degradation organelle involved in the proteolysis of the host erythrocyte's haemoglobin; it is the site of action of several antimalarial drugs and its membrane harbours transporters implicated in drug resistance ...
Yvonne, Kuhn +5 more
openaire +2 more sources