Results 71 to 80 of about 6,004 (229)

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

Malaria Journal, 2008
Background The insertion of parasite antigens into the host erythrocyte membrane and the structure and distribution of Plasmodium falciparum adhesion receptors on that membrane are poorly understood.
Arnot David E, Theander Thor G, Turner Louise, Joergensen Louise, Jensen Anja TR, Salanti Ali, Sowa Kordai M, Bengtsson Dominique   +7 more
doaj   +1 more source

Optimized Purification of CIDRα-PfEMP1 Plasmodium falciparum Recombinant Protein with Affinity Chromatography

Jurnal Ilmu Dasar, 2022
Interaction of Cysteine-rich Interdomain Region (CIDR)α-Plasmodium falciparum Erythrocyte Membrane Protein (PfEMP1) and Endothelial Cell Receptors especially CD36 on host cells is main malaria pathogenesis, makes this domain as a malaria vaccine ...
Eqiel Navadz Akthar Alami, Erma Sulistyaningsih, Irawan Fajar Kusuma, Sheilla Rachmania   +3 more
doaj   +1 more source

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1. [PDF]

PLoS Pathogens, 2010
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria.
Louise Joergensen, Dominique C Bengtsson, Anja Bengtsson, Elena Ronander, Sanne S Berger, Louise Turner, Michael B Dalgaard, Gerald K K Cham, Michala E Victor, Thomas Lavstsen, Thor G Theander, David E Arnot, Anja T R Jensen   +12 more
doaj   +1 more source

Knobs, Adhesion, and Severe Falciparum Malaria

Tropical Medicine and Infectious Disease, 2023
Plasmodium falciparum can cause a severe disease with high mortality. A major factor contributing to the increased virulence of P. falciparum, as compared to other human malarial parasites, is the sequestration of infected erythrocytes in the capillary ...
Mark F. Wiser
doaj   +1 more source

Sensitive real-time PCR detection of Plasmodium falciparum parasites in whole blood by erythrocyte membrane protein 1 gene amplification

Malaria Journal, 2019
Background Malaria remains a global public health problem responsible for 445,000 deaths in 2016. While microscopy remains the mainstay of malaria diagnosis, highly sensitive molecular methods for detection of low-grade sub-microscopic infections are ...
Bryan Grabias, Edward Essuman, Isabella A. Quakyi, Sanjai Kumar   +3 more
doaj   +1 more source

Epistatic Interactions Among Co‐Inherited Malaria‐Protective Red Blood Cell Polymorphisms and Their Effects Across the Infection‐Mortality Spectrum in Endemic Populations: A Systematic Review

Anemia, Volume 2026, Issue 1, 2026.
Background Malaria remains a major global health burden, with red blood cell (RBC) polymorphisms conferring partial protection. However, the epistatic interactions among co‐inherited RBC polymorphisms are poorly understood. We aimed to characterise how epistatic interactions among malaria‐protective RBC polymorphisms modify risk across the infection‐to‐
George Paasi, Ruth Namazzi, Glorias Asiimwe, Grace Ndeezi, Joseph Rujumba, Christine Sekaggya-Wiltshire, Ezekiel Mupere, Ian Guyton Munabi, Sarah Kiguli, Richard Idro, Peter Olupot-Olupot, Duran Canatan   +11 more
wiley   +1 more source

Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes. [PDF]

, 2004
Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P.
Chiucchiuini, Antonella, Christensen, Jesper, Hermsen, Rob, Hviid, Lars, Jensen, Anja TR, Joergensen, Louise, Lavstsen, Thomas, Lusingu, John P, Magistrado, Pamela, Nielsen, Morten A, Salanti, Ali, Sauerwein, Robert, Sharp, Sarah, Staalsoe, Trine, Sutherland, Colin, Theander, Thor G, Vestergaard, Lasse S   +16 more
core   +12 more sources

Author Correction: IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria [PDF]

, 2021
Cyril Badaut, Pimnitah Visitdesotrakul, Aurélie Chabry, Pascal Bigey, Bernard Tornyigah, Jocelyne Roman, Jules Alao Maroufou, Annick Amoussou, B Ayivi, Gratien Sagbo, Nicaise Tuikue Ndam, Andrew V. Oleinikov, Rachida Tahar   +12 more
openalex   +1 more source

Integrating Aggregate Materials and Machine Learning Algorithms: Advancing Detection of Pathogen‐Derived Extracellular Vesicles

Aggregate, Volume 6, Issue 5, May 2025.
Pathogen‐derived extracellular vesicle detection: theoretical insights and advanced methodologies: This review explores the theoretical foundations and practical applications of pEV detection, emphasizing the challenges and innovative strategies involving novel aggregate materials and machine learning for enhanced diagnostic accuracy.
Lihan Lai, Yun Su, Cong Hu, Zehong Peng, Wei Xue, Liang Dong, Tony Y. Hu   +6 more
wiley   +1 more source

A New method for the capture of surface proteins in Plasmodium falciparum parasitized erythrocyte [PDF]

, 2012
Introduction: We propose a new method for the selective labeling, isolation and electrophoretic analysis of the Plasmodium falciparum protein exposed on the erythrocyte cell surface.
Ferru, Emanuela, Pantaleo, Antonella, Turrini, Francesco Michelangelo   +2 more
core