Results 171 to 180 of about 3,285 (205)

Decoding Ethiopia’s unique and structurally divergent Plasmodium falciparum populations using genomics

Osborne AA, Assefa A, Degaga TS, Hailu A, Woyessa A, Tadesse D, Rai A, Rumaseb A, Trimarsanto H, Kwiatkowski D, Lee CY, Pearson RD, Price RN, Thriemer K, Auburn S.   +14 more
europepmc   +1 more source

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport [PDF]

MBio, 2020
Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia.
David Fidock, Vandana Thathy, Maria Isabel Veiga   +2 more
exaly   +2 more sources

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Contribution of the pfmdr1 gene to antimalarial drug-resistance

Acta Tropica, 2005
The emergence of drug-resistance poses a major obstacle to the control of malaria. A homolog of the major multidrug-transporter in mammalian cells was identified, Plasmodium falciparum multidrug resistance protein-1, pfmdr1, also known as the P-glycoprotein homolog 1, Pgh-1.
Manoj T, Duraisingh, Alan F, Cowman
openaire   +2 more sources

pfmdr1 mutations in imported African Plasmodium falciparum isolates

Transactions of the Royal Society of Tropical Medicine and Hygiene, 2008
Amodiaquine/artesunate and artemether/lumefantrine are currently implemented as antimalarial drugs in Africa. In this study, we assessed Plasmodium falciparum pfmdr1 alleles suggesting reduced sensitivity to amodiaquine/artesunate (86Y-184Y-1246Y) and artemether/lumefantrine (184F and 86N-184F-1246D) in 111 African isolates imported to Germany between ...
Anja K, Dippmann, Ulrich, Bienzle, Gundel, Harms, Frank P, Mockenhaupt   +3 more
openaire   +2 more sources

Polymorphism of the Pfmdr1 gene and chloroquine resistance in Plasmodium falciparum in The Gambia

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997
To assess the level of resistance to chloroquine (CQ) of Plasmodium falciparum in The Gambia in 1995-1996 we measured susceptibility in vivo by quantifying parasitaemia of children with mild malaria on days 4 and 8 after treatment. Pretreatment blood samples were used for susceptibility testing in vitro by the World Health Organization microtest and ...
L, von Seidlein, M T, Duraisingh, C J, Drakeley, R, Bailey, B M, Greenwood, M, Pinder   +5 more
openaire   +2 more sources

A high number of pfmdr1 gene copies in P. falciparum from Venezuela

Parasitology Research, 2019
Multidrug resistance in Plasmodium falciparum has been associated with gene amplification of pfmdr1. We studied the corresponding gene amplification in P. falciparum from blood samples of malaria patients in the Sifontes Municipality, Bolívar State, Venezuela, known as the highest region of incidence of malaria. Fifty-five P.
Flor Herrera, Cesar Pacheco
exaly   +3 more sources

Mutation in pfmdr1 gene in chloroquine-resistant Plasmodium falciparum isolates, Southeast Iran [PDF]

International Journal of Infectious Diseases, 2008
The main objective of the present study was to detect point mutations at positions 86, 184, 1034, 1042, and 1246 of the Plasmodium falciparum multidrug resistance gene (pfmdr1) in blood samples collected from malaria patients in Chabahar, a harbor city located in Southeast Iran.Twenty-six blood samples from patients infected with P. falciparum, who had
Abdolhossein Dalimi, Siamak Mirab Samiee, Fatemeh Ghaffarifar   +2 more
exaly   +3 more sources

Alleles of the Plasmodium falciparum Pfmdr1 gene appear not to be associated with chloroquine resistance in India

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997
L Kabilan
exaly   +3 more sources

Multiplex PCR–RFLP methods for pfcrt, pfmdr1 and pfdhfr mutations in Plasmodium falciparum

Molecular and Cellular Probes, 2006
Plasmodium falciparum drug resistance is a major factor for the death toll of malaria. Resistance has been associated with specific single nucleotide polymorphisms (SNPs) in the parasite genes pfmdr1 (N86Y) and pfcrt (K76T) associated with quionoline antimalarial resistance, and pfdhfr (N51I, C59R, S108N) correlated with resistance of the antifolate ...
Maria Isabel Veiga, Ferreira Pe, Gil Jp   +2 more
exaly   +3 more sources

Association of pfcrt But Not pfmdr1 Alleles with Chloroquine Resistance in Iranian Isolates of Plasmodium falciparum

The American Journal of Tropical Medicine and Hygiene, 2008
This study was designed to analyze the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance 1 (pfmdr1) mutations as markers of chloroquine (CQ) resistance in 200 blood samples collected from malaria patients in south-eastern Iran during 2002–2005.
Sedigheh, Zakeri, Mandana, Afsharpad, Tahmineh, Kazemzadeh, Kambiz, Mehdizadeh, Ashraf, Shabani, Navid Dinparast, Djadid   +5 more
openaire   +2 more sources