Results 1 to 10 of about 49,868 (226)

Epigenetic Modifications of the PGC-1α Promoter during Exercise Induced Expression in Mice [PDF]

PLoS ONE, 2015
The transcriptional coactivator, PGC-1α, is known for its role in mitochondrial biogenesis. Although originally thought to exist as a single protein isoform, recent studies have identified additional promoters which produce multiple mRNA transcripts. One
Bennett, James P., Jr., Lochmann, Timothy L., Taylor, Shirley M., Thomas, Ravindar R.   +3 more
core   +20 more sources

Cerebellar transcriptional alterations with Purkinje cell dysfunction and loss in mice lacking PGC-1α [PDF]

Frontiers in Cellular Neuroscience, 2015
Alterations in the expression and activity of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α (ppargc1a or PGC-1α) have been reported in multiple movement disorders, yet it is unclear how a lack of PGC-1α impacts transcription and function of the cerebellum, a region with high PGC-1α expression.
Elizabeth K Lucas, Elizabeth K Lucas, Courtney S. Reid, Laura J. McMeekin, Sarah E. Dougherty, Sarah E. Dougherty, Candace L. Floyd, Rita Marie Cowell   +7 more
openaire   +4 more sources

The Asymmetric Binding of PGC-1α to the ERRα and ERRγ Nuclear Receptor Homodimers Involves a Similar Recognition Mechanism [PDF]

PLoS ONE, 2013
PGC-1α is a crucial regulator of cellular metabolism and energy homeostasis that functionally acts together with the estrogen-related receptors (ERRα and ERRγ) in the regulation of mitochondrial and metabolic gene networks. Dimerization of the ERRs is a pre-requisite for interactions with PGC-1α and other coactivators, eventually leading to ...
Takacs, Maria, V. Petoukhov, Maxim, Atkinson, Robert, Roblin, Pierre, Ogi, François-Xavier, Demeler, Borries, Potier, Noëlle, Chebaro, Yassmine, Dejaegere, Annick, Svergun, Dmitri, Moras, Dino, Billas, Isabelle   +11 more
openaire   +6 more sources

Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles [PDF]

, 2020
This study aimed to investigate the long-term effects of training intervention and resting on protein expression and stability of peroxisome proliferator-activated receptor β/δ (PPARβ), peroxisome proliferator-activated receptor gamma coactivator 1-α ...
Holloszy, John O, Kim, Kijin, Koh, Jin-Ho, Park, Ju-Sik   +3 more
core   +2 more sources

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity [PDF]

, 2011
The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and ...
Handschin, C., Santos, G., Summermatter, S., Troxler, H.   +3 more
core   +1 more source

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α [PDF]

, 2007
Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty acid oxidation, and mitochondrial biogenesis by increasing gene expression in these pathways.
Jager, S., Handschin, C., St-Pierre, J., Spiegelman, B. M.   +3 more
core   +2 more sources

Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]

, 2015
Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal, Aitchison, Altschul, Andersson, Blows, Blows, Bonduriansky, Brooks, Chenoweth, Chenoweth, Chung, Connallon, Coyne, Dallerac, Darwin, Doerge, Eyre-Walker, Fang, Ferreira, Ferveur, Fiumera, Frentiu, Gibbs, Gosden, Haldane, Hereford, Hine, Hine, Hine, Howard, Howard, Johnston, Kennington, Kingsolver, Kistler, Labeur, Lande, Long, Magwire, Mousseau, Park, Rako, Reinhart, Ritchie, Roff, Rundle, Sall, Siller, Swanson, Wagner, Weeks, Wilkinson, Zhang   +52 more
core   +4 more sources

Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]

, 2004
The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Fan, M., Rhee, J., St-Pierre, J., Handschin, C., Puigserver, P., Lin, J., Jaeger, S., Erdjument-Bromage, H., Tempst, P., Spiegelman, B. M.   +9 more
core   +1 more source

The Genomic Context and Corecruitment of SP1 Affect ERRα Coactivation by PGC-1α in Muscle Cells [PDF]

, 2016
The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) coordinates the transcriptional network response to promote an improved endurance capacity in skeletal muscle, eg, by coactivating the estrogen-related receptor-α (ERRα) in the ...
Baresic, Mario, Handschin, Christoph, Kupr, Barbara, Salatino, Silvia, van Nimwegen, Erik   +4 more
core   +1 more source

Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice [PDF]

, 2016
Ketone bodies (KBs) are crucial energy substrates during states of low carbohydrate availability. However, an aberrant regulation of KB homeostasis can lead to complications such as diabetic ketoacidosis.
Albert, Verena, Cardel, Bettina, Handschin, Christoph, Salatino, Silvia, Svensson, Kristoffer   +4 more
core   +1 more source