Results 131 to 140 of about 49,868 (226)

Exercise‐related microRNAs in Caenorhabditis elegans regulate calcium homeostasis and mitochondrial dynamics: Conserved pathways, divergent microRNAs

The FEBS Journal, EarlyView.
Exercise‐related microRNAs cel‐miR‐249‐3p and cel‐miR‐77‐5p in C. elegans regulate lifespan, fitness, mitochondrial morphology and membrane potential. Although lacking direct mammalian orthologs, H2O2‐induced microRNAs mmu‐miR‐181a‐5p and mmu‐miR‐378a‐3p regulate myogenesis, autophagy, mitochondrial content and respiration in murine myoblasts ...
Qin Xia, Jiwang Tang, José C. Casas‐Martinez, Penglin Li, Maria Borja‐Gonzalez, Leo R Quinlan, Katarzyna Goljanek‐Whysall, Brian McDonagh   +7 more
wiley   +1 more source

PPAR gamma-coactivator-1 alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model [PDF]

, 2016
Current therapies for Alzheimer’s disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss.
Birch, AM, Blondrath, K, Eleftheriadou, I, Irvine, EE, Katsouri, L, Lim, YM, Lombardero, L, Mazarakis, ND, Mirzaei, N, Sastre, M   +9 more
core  

Histological characterisation of gonadal sex differentiation in Malabar red snapper (Lutjanus malabaricus) for aquaculture advancement

Journal of Fish Biology, EarlyView.
Abstract The Malabar red snapper (Lutjanus malabaricus) is a high‐value tropical marine species receiving growing attention for aquaculture development in Singapore and Southeast Asia. At present, seed production relies primarily on uncontrolled mass spawning in sea cages, a practice that lacks consistency, biosecurity and control of genetic ...
Bing Liang, Dean R. Jerry, Joyce Koh, Purushothaman Kathiresan, Celestine Terence, Xueyan Shen, Grace Loo, Shubha Vij, Jose A. Domingos   +8 more
wiley   +1 more source

Architecture of lower leg muscles in children: Reference curves and potential mechanisms of growth

Journal of Anatomy, EarlyView.
Muscle architecture (physiological cross‐sectional area, fascicle lengths and pennation angle) was measured from multimodal MRI scans of the lower legs of 197 children aged ≤15 years. We showed that lower leg muscle volumes (product of PCSA and fascicle length) increase primarily through increases in PCSA (transverse growth) rather than increases in ...
Brian V. Y. Chow, Suzanne Davies, Catherine Morgan, Caroline D. Rae, David I. Warton, Iona Novak, Ann Lancaster, Gordana C. Popovic, Rodrigo R. N. Rizzo, Claudia Y. Rizzo, Iain K. Ball, Robert D. Herbert, Bart Bolsterlee   +12 more
wiley   +1 more source

Diagnosing and Treating Periodontitis and Multimorbidity Altogether: The Case Example of the Physical Exercise Hormone Irisin

Journal of Periodontal Research, EarlyView.
Irisin is an extracellular peptide stimulated by exercise and could act as both a biomarker and mediate the positive impact of exercise. This scoping review synthesizes human evidence on irisin variations in non‐communicable diseases, showing an increase of irisin in saliva and gingival tissues in periodontitis, potentially reflecting reparative or ...
Larysa Saboya Cavalotti Perdonsini, Rafael Scaf de Molon, Søren Jepsen, Iain Chapple, Joao Paulo Steffens   +4 more
wiley   +1 more source

Vast, overlooked peat, and organic soils in Brazil's Cerrado: carbon storage, dynamics, and stability

New Phytologist, EarlyView.
Summary Tropical peatlands are critical for climate mitigation due to their dual role as major carbon sinks and methane sources. In rainforests, high and stable rainfall supports peat accumulation in tropical climates. However, groundwater‐fed peatlands in seasonally dry tropical ecosystems remain poorly understood, despite their potential importance ...
Larissa S. Verona, Amy E. Zanne, Susan Trumbore, Paulo N. Bernardino, Guilherme M. Alencar, Thalia Andreuccetti, David Herrera‐Ramírez, João C. F. Cardoso, Demetrius Lira‐Martins, Guilherme G. Mazzochini, Natashi Pilon, Rafael S. Oliveira   +11 more
wiley   +1 more source

Effect of Citrus bergamia Supplementation on Body Composition in Humans: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Obesity Reviews, EarlyView.
ABSTRACT This systematic review and meta‐analysis of randomized controlled trials (RCTs) was conducted to assess the effect of nutraceuticals containing Citrus bergamia on the management of obesity in adults by assessing measures related to obesity. We searched the following databases until October 2024: PubMed, Web of Science, Scopus, and the Cochrane
Carmelo Pujia, Yvelise Ferro, Alberto Castagna, Elisa Mazza, Samantha Maurotti, Francesca Rita Noto, Valeria Rizzo, Tiziana Montalcini, Arturo Pujia   +8 more
wiley   +1 more source

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

Examining the correspondence between political ideology and gun policy attitudes among Black and White people in the United States

Political Psychology, EarlyView.
Abstract The present research examined whether political ideology corresponded with gun attitudes among people disproportionately experiencing gun violence—Black people in the United States. Across four studies (N = 25,847) we found that race (Black vs.
Joy E. Losee, Gerald D. Higginbotham, Gaby C. Pogge, Liz Kerner, James A. Shepperd   +4 more
wiley   +1 more source