PGC-1α expression in murine AgRP neurons regulates food intake and energy balance [PDF]
Molecular Metabolism, 2016 Food intake and whole-body energy homeostasis are controlled by agouti-related protein (AgRP) and pro-opiomelanocortin (POMC) neurons located in the arcuate nucleus of the hypothalamus.
Delezie, Julien +3 more
core +5 more sources
Brain Sciences, 2021 The pharmacological induction and activation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), a key regulator of ischemic brain tolerance, is a promising direction in neuroprotective therapy.
Fatima M. Shakova +4 more
doaj +1 more source
Glucocorticoids Alter CRTC-CREB Signaling in Muscle Cells: Impact on PGC-1α Expression and Atrophy Markers. [PDF]
PLoS ONE, 2016 Muscle wasting associated with chronic diseases has been linked to decreased expression of PGC-1α and overexpression of PGC-1α counters muscle loss. CREB, in conjunction with the CREB-regulated transcription coactivator (CRTC2), is a positive modulator ...
Jill A Rahnert +4 more
doaj +1 more source
Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α. [PDF]
PLoS ONE, 2016 The β3-adrenergic receptor (AR) signaling pathway is a major component of adaptive thermogenesis in brown and white adipose tissue during cold acclimation.
Jihyun Kim +7 more
doaj +1 more source
Covering the Role of PGC-1α in the Nervous System
Cells, 2021 The peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a well-known transcriptional coactivator involved in mitochondrial biogenesis.
Zuzanna Kuczynska +3 more
doaj +1 more source
ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. [PDF]
PLoS ONE, 2010 Atherosclerosis is a chronic inflammatory disease that evolves from the interaction of activated endothelial cells, macrophages, lymphocytes and modified lipoproteins (LDLs).
Sokrates Stein +6 more
doaj +1 more source
Developmental alterations in motor coordination and medium spiny neuron markers in mice lacking pgc-1α. [PDF]
PLoS ONE, 2012 Accumulating evidence implicates the transcriptional coactivator peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) in the pathophysiology of Huntington Disease (HD).
Elizabeth K Lucas +5 more
doaj +1 more source
Scientific Reports, 2021 Transcriptional coactivator PGC-1α and its splice variant NT-PGC-1α regulate metabolic adaptation by modulating many gene programs. Selective ablation of PGC-1α attenuates diet-induced obesity through enhancing fatty acid oxidation and thermogenesis by ...
Jihyun Kim +6 more
doaj +1 more source
PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues. [PDF]
Cell BiosciPeroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a crucial coactivator that regulates mitochondrial biogenesis and function across diverse tissues, including the brain, heart, skeletal muscle, bone marrow, and liver.
Cao L +9 more
europepmc +2 more sources
Skeletal muscle-specific PGC-1α-b overexpression prevents eccentric contraction-induced muscle injury through an utrophin-independent pathway in mice. [PDF]
Physiol RepSlower oxidative fibers are more resistant to eccentric contraction (ECC)‐induced muscle damage than fast‐twitch glycolytic fibers, but the mechanisms remain unclear. This study investigated the roles of the exercise‐inducible PGC‐1α isoform PGC‐1α‐b and
Naito A +7 more
europepmc +2 more sources