Results 21 to 30 of about 49,868 (226)

Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation

Genome Medicine, 2021
Background Neuroinflammation and immune responses occurring minutes to hours after stroke are associated with brain injury after acute ischemic stroke (AIS).
Bin Han, Wei Jiang, Pan Cui, Kai Zheng, Chun Dang, Junjie Wang, He Li, Lin Chen, Rongxin Zhang, Qing Mei Wang, Zhenyu Ju, Junwei Hao   +11 more
doaj   +1 more source

NT-PGC-1α deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo

Journal of Lipid Research, 2018
Transcriptional coactivator PPAR γ coactivator (PGC)-1α and its splice variant N-terminal (NT)-PGC-1α mediate transcriptional regulation of brown adipose tissue (BAT) thermogenesis in response to changes in ambient temperature.
Jihyun Kim, Min Sung Park, Kyoungsoo Ha, Chulhong Park, Jisu Lee, Randall L. Mynatt, Ji Suk Chang   +6 more
doaj   +1 more source

Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway

Behavioural Neurology, 2021
Background and Aim. Increasing evidence suggests that the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)/fibronectin type III domain-containing 5 (FNDC5)/brain-derived neurotrophic factor (BDNF) pathway might be critical for ...
Yanqin Wu, Fusheng Sun, Yujin Guo, Yumao Zhang, Li Li, Ruili Dang, Pei Jiang   +6 more
doaj   +1 more source

Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism

PPAR Research, 2012
Brown fat expresses two PGC-1α isoforms (PGC-1α and NT-PGC-1α) and both play a central role in the regulation of cellular energy metabolism and adaptive thermogenesis by interacting with a wide range of transcription factors including PPARγ, PPARα, ERRα,
Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang   +2 more
doaj   +1 more source

PGC-1α inhibits M2 macrophage polarization and alleviates liver fibrosis following hepatic ischemia reperfusion injury

Cell Death Discovery, 2023
Oxidative stress can induce inflammation, promoting macrophage polarization and liver fibrosis following hepatic ischemia-reperfusion (I/R). Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has anti-oxidant and anti-inflammatory ...
Yanting Zhang, Linzhong Zhang, Yanmian Zhao, Jing He, Yanghao Zhang, Xiuying Zhang   +5 more
doaj   +1 more source

Quercetin and Quercetin-Rich Red Onion Extract Alter Pgc-1α Promoter Methylation and Splice Variant Expression

PPAR Research, 2017
Pgc-1α and its various isoforms may play a role in determining skeletal muscle mitochondrial adaptations in response to diet. 8 wks of dietary supplementation with the flavonoid quercetin (Q) or red onion extract (ROE) in a high fat diet (HFD ...
Prasad P. Devarshi, Aarin D. Jones, Erin M. Taylor, Barbara Stefanska, Tara M. Henagan   +4 more
doaj   +1 more source

Peroxisome Proliferator Activator Receptor Gamma Coactivator-1α Overexpression in Amyotrophic Lateral Sclerosis: A Tale of Two Transgenics

Biomolecules, 2020
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder manifesting with upper and lower neuron loss, leading to impairments in voluntary muscle function and atrophy.
Merina Varghese, Wei Zhao, Kyle J. Trageser, Giulio M. Pasinetti   +3 more
doaj   +1 more source

PGC-1α Is a Master Regulator of Mitochondrial Lifecycle and ROS Stress Response

Antioxidants, 2023
Mitochondria play a major role in ROS production and defense during their life cycle. The transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism and is therefore closely linked to mitochondrial function.
Othman Abu Shelbayeh, Tasnim Arroum, Silke Morris, Karin B. Busch   +3 more
doaj   +1 more source

PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism

Molecular Metabolism, 2018
Objective: Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) promotes hepatic gluconeogenesis by activating HNF4α and FoxO1.
Jaemin Lee, Mario Andrés Salazar Hernández, Thomas Auen, Patrick Mucka, Justin Lee, Umut Ozcan   +5 more
doaj   +1 more source

PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts [PDF]

Genetics and Molecular Biology, 2020
The XPC protein, which is mutated in xeroderma pigmentosum (XP) complementation group C (XP-C), is a lesion recognition factor in NER, but it has also been shown to interact with and stimulate DNA glycosylases, to act as transcriptional co-activator and ...
Mateus Prates Mori, Nadja Cristhina de Souza-Pinto   +1 more
doaj   +1 more source