Partnership of PGC-1α and HNF4α in the regulation of lipoprotein metabolism [PDF]
, 2006 Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional coactivator involved in several aspects of energy metabolism. It is induced or activated under different stimuli in a highly tissue-specific manner and subsequently
Cooper, M. +8 more
core +1 more source
Frontiers in Endocrinology, 2021 Atherosclerosis (AS) is the main cause of morbidity and mortality in the world. Mitochondrial dysfunction is closely related to AS. At present, several signaling pathways related to mitochondrial dysfunction have been found, one of which is around PGC-1α.
Guiming Wang +6 more
doaj +1 more source
Muscle PGC-1α modulates satellite cell number and proliferation by remodeling the stem cell niche [PDF]
, 2016 BACKGROUND: The myogenic capacity of satellite cells (SCs), adult muscle stem cells, is influenced by aging, exercise, and other factors. In skeletal muscle, the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a key regulator of ...
Beer, Markus +5 more
core +3 more sources
Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury
Neural Plasticity, 2022 Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis.
Bin Han +6 more
doaj +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin [PDF]
, 2014 Background: Duchenne muscle dystrophy (DMD) afflicts 1 million boys in the US and has few effective treatments. Constitutive transgenic expression of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α ...
Arany, Zolt +5 more
core +1 more source
PGC-1α in Disease: Recent Renal Insights into a Versatile Metabolic Regulator
Cells, 2020 Peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1α) is perhaps best known as a master regulator of mitochondrial biogenesis and function.
Joseph M. Chambers, Rebecca A. Wingert
doaj +1 more source
PGC-1α determines light damage susceptibility of the murine retina. [PDF]
PLoS ONE, 2012 The peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) proteins are key regulators of cellular bioenergetics and are accordingly expressed in tissues with a high energetic demand.
Anna Egger +13 more
doaj +1 more source
l-Citrulline Supplementation-Increased Skeletal Muscle PGC-1α Expression Is Associated with Exercise Performance and Increased Skeletal Muscle Weight [PDF]
, 2018 1 Scopel‐citrulline has recently been reported as a more effective supplement for promoting intracellular nitric oxide (NO) production compared to l‐arginine.
Isoda Hiroko +3 more
core +2 more sources
PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes
Frontiers in Physiology, 2018 The transcriptional coactivators peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) and PGC-1β are positive regulators of skeletal muscle mass and energy metabolism; however, whether they influence muscle growth and metabolic ...
Erin L. Brown +9 more
doaj +1 more source