PGC-1α affects aging-related changes in muscle and motor function by modulating specific exercise-mediated changes in old mice [PDF]
, 2018 The age-related impairment in muscle function results in a drastic decline in motor coordination and mobility in elderly individuals. Regular physical activity is the only efficient intervention to prevent and treat this age-associated degeneration ...
Arnold +43 more
core +1 more source
Rosiglitazone-induced mitochondrial biogenesis in white adipose tissue is independent of peroxisome proliferator-activated receptor γ coactivator-1α. [PDF]
PLoS ONE, 2011 BackgroundThiazolidinediones, a family of insulin-sensitizing drugs commonly used to treat type 2 diabetes, are thought to exert their effects in part by promoting mitochondrial biogenesis in white adipose tissue through the transcriptional coactivator ...
Rosario Pardo +5 more
doaj +1 more source
Moderate Modulation of Cardiac PGC-1α Expression Partially Affects Age-Associated Transcriptional Remodeling of the Heart [PDF]
, 2018 Aging is associated with a decline in cardiac function due to a decreased myocardial reserve. This adverse cardiac remodeling comprises of a variety of changes, including a reduction in mitochondrial function and a decline in the expression of the ...
Brink, Marijke +3 more
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Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α. [PDF]
PLoS ONE, 2015 Peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α) is a coactivator of various nuclear receptors and other transcription factors whose expression increases in the skeletal muscle during exercise.
Yukino Hatazawa +6 more
doaj +1 more source
Effects of resveratrol and SIRT1 on PGC-1α activity and mitochondrial biogenesis: A reevaluation [PDF]
, 2013 It has been reported that feeding mice resveratrol activates AMPK and SIRT1 in skeletal muscle leading to deacetylation and activation of PGC-1α, increased mitochondrial biogenesis, and improved running endurance.
Asaka, Meiko +5 more
core +4 more sources
Journal of Lipid Research, 2012 Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a key regulator of energy metabolism and lipid homeostasis in multiple highly oxidative tissues, has been implicated in the metabolic derangements of diabetes and obesity. However,
Michael A. Kiebish +3 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
The coactivator PGC-1α regulates mouse skeletal muscle oxidative metabolism independently of the nuclear receptor PPARβ/δ in sedentary mice fed a regular chow diet [PDF]
, 2014 AIMS/HYPOTHESIS: Physical activity improves oxidative capacity and exerts therapeutic beneficial effects, particularly in the context of metabolic diseases.
Handschin, C. +5 more
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PGC-1α is associated with Schizothorax prenanti myoblast differentiation
Journal of Applied Animal Research, 2018 PGC-1α has been considered as an important mediator of functional capacity of muscle. Our previous study indicated that the mRNA level of PGC-1α increased in muscle during Schizothorax prenanti (S. prenanti) growth.
Yanying Zhao +3 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source