Post-ischaemic treatment with the cyclooxygenase-2 inhibitor nimesulide reduces blood-brain barrier disruption and leukocyte infiltration following transient focal cerebral ischaemia in rats [PDF]
Journal of Neurochemistry 100(4): 1108-1120 (2007), 2007 Several studies suggest that cyclooxygenase (COX)-2 plays a pivotal role in the progression of ischaemic brain damage. In the present study, we investigated the effects of selective inhibition of COX-2 with nimesulide (12 mg/kg) and selective inhibition of COX-1 with valeryl salicylate (VAS, 12-120 mg/kg) on prostaglandin E2 (PGE2) levels ...
Candelario-Jalil, Eduardo +4 more
arxiv +4 more sources
Statin Gastroprotective Mechanisms Independent of Gastric Acid Suppression [PDF]
المجلة العراقية للصيدلة, 2023 Background: Statins have demonstrated various beneficial clinical outcomes, not only in patients with elevated cholesterol levels but also in those with normal levels, a collective phenomenon known as pleiotropic effects.
Dilgash Abdullah, Hani Almukhtar
doaj +1 more source
Role of PGE2 receptors in RA [PDF]
Arthritis Research & Therapy, 2002 Elaine A. Lidington
openalex +3 more sources
Turkish Journal of Agriculture: Food Science and Technology, 2021 In this study, it was aimed to investigate the effect of evening primrose oil (EPO) on some biochemical parameters on nephrotoxicity induced by gentamicin (GM) in rats.
Murat Medineli +3 more
doaj +1 more source
Immune Response in Pregnant Women Infected with Acute Vaginal Abscess Caused by Staphylococcus aureus and Trichomonas vaginalis [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Vaginal abscess in pregnant women caused by Staphylococcus aureus and Trichomonas vaginalis is one of the most important disease. This infection is still medically uncontrolled because of poor health awareness due to the absence of personal
Ahmed Abduljabbar Jaloob Aljanaby +2 more
doaj +1 more source
Is There a Role for PGE2 in Urinary Concentration? [PDF]
Journal of the American Society of Nephrology, 2013 Prostanoids are prominent, yet complex, components in the maintenance of body water homeostasis. Recent functional and molecular studies have revealed that the local lipid mediator PGE2 is involved both in water excretion and absorption. The biologic actions of PGE2 are exerted through four different G-protein-coupled receptors; designated EP1-4, which
Olesen, Emma T B, Fenton, Robert A.
openaire +4 more sources
Estradiol-17β, Prostaglandin E2 (PGE2), and the PGE2 Receptor Are Involved in PGE2 Positive Feedback Loop in the Porcine Endometrium [PDF]
Endocrinology, 2009 Before implantation, the porcine endometrium and trophoblast synthesize elevated amounts of luteoprotective prostaglandin estradiol-17beta (E(2)) (PGE(2)). We hypothesized that embryo signal, E(2), and PGE(2) modulate expression of key enzymes in PG synthesis: PG-endoperoxide synthase-2 (PTGS2), microsomal PGE synthase (mPGES-1), PGF synthase (PGFS ...
Henry N. Jabbour +3 more
openaire +3 more sources
15-Keto-PGE2 acts as a biased/partial agonist to terminate PGE2-evoked signaling [PDF]
Journal of Biological Chemistry, 2020 Prostaglandin E2 (PGE2) is well-known as an endogenous proinflammatory prostanoid synthesized from arachidonic acid by the activation of cyclooxygenase-2. E type prostanoid (EP) receptors are cognates for PGE2 that have four main subtypes: EP1 to EP4.
Suzu Endo +8 more
openaire +3 more sources
Wnt signaling enhances macrophage responses to IL-4 and promotes resolution of atherosclerosis
eLife, 2021 Atherosclerosis is a disease of chronic inflammation. We investigated the roles of the cytokines IL-4 and IL-13, the classical activators of STAT6, in the resolution of atherosclerosis inflammation.
Ada Weinstock +21 more
doaj +1 more source
Microorganisms, 2020 Mycobacterium bovis (M. bovis) is a zoonotic pathogen that causes bovine and human tuberculosis. Dendritic cells play a critical role in initiating and regulating immune responses by promoting antigen-specific T-cell activation.
Han Liu +11 more
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