Results 51 to 60 of about 60,514 (230)

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

A Single‐Cell Transcriptomic Atlas of the Ovine Rumen Microbiome Characterizes Lineage‐Specific Metabolic Shifts Associated with Host Heat Tolerance

Advanced Science, EarlyView.
An optimized single‐cell transcriptomic framework profiles over 60 000 cells to map the ovine rumen microbiome, partitioning the ecosystem into seven cross‐species functional clusters. In heat‐resistant hosts, a lineage‐specific metabolic shift in Anaerovibrio lipolyticus toward a highly glycolytic phenotype contributes to a “nutritional sparing ...
Sanbao Zhang, Qinyang Jiang, Junjie Ma, Jianwei Zou, Fan Wang, Feifei Lv, Yanna Huang, Yongcheng Wang, Ziye Xu   +8 more
wiley   +1 more source

Determination of the minimal PGK region required for actin binding activity.

, 2013
(A) Far Western experiment performed on Ciha-1 cell proteins overlaid with His6-tagged PGK and His6-tagged PGK truncations. Lane 1, gel electrophoresis pattern of Ciha-1 cell proteins stained with colloidal blue.
Nathalie Arricau-Bouvery (17976), Laure Béven (123889), Fabien Labroussaa (160578), Colette Saillard (123900), Marie-Pierre Dubrana (123897)   +4 more
core   +1 more source

Recent Advances (2023–2025) of Capillary Electrophoresis‐Mass Spectrometry (CE‐MS) for Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu, David A. Alvarez Rodriguez, Noah Gould, Alexander R. Ivanov, Kevin Jooß, Liangliang Sun   +5 more
wiley   +1 more source

Menurunkan intensitas nyeri pemasangan arteriovena fistula pada pasien hemodialisis menggunakanteknik valsava maneuver

Ners Muda
Hemodialisis (HD) adalah pilihan utama dalam perawatan pada pasien penyakit ginjal kronis (PGK). Sejak menjalani HD pasien biasanya mengalami dua kanulasi di fistula mereka dua kali per minggu dan mengalami nyeri jarum setidaknya 192 kali setahun.
Suramadhan Suramadhan, Khoiriyah Khoiriyah, Nury Sukraeny, Yunie Armiyati   +3 more
doaj   +1 more source

Histiocytosis development and clinical variation through the lens of genomics

The Journal of Pathology, EarlyView.
Abstract Histiocytic neoplasms are rare haematologic diseases characterised by clonal expansions of cells with a monocyte, macrophage or dendritic cell phenotype. Their clinical manifestations are diverse, ranging from indolent lesions to aggressive systemic disease.
Paul G Kemps, Astrid GS van Halteren, Tom van Wezel, Pancras CW Hogendoorn   +3 more
wiley   +1 more source

Growth rates and PGK cell lysate activities.

, 2013
Plotted are growth rates (open symbols, right Y axis) and levels of PGK enzymatic activity in crude cell lysates (closed symbols, left Y axis) as a function of the expression inducer (AHT) concentration. Shown are the parental E.
Maria Raitses Gurevich (437272), Dan S. Tawfik (42531), Alon Wellner (437271)   +2 more
core   +1 more source

Phosphoglycerate Kinase 1: An Effective Therapeutic Target in Cancer

Frontiers in Bioscience-Landmark
Phosphoglycerate kinase 1 (PGK1) serves as a pivotal enzyme in the cellular glycolysis pathway, facilitating adenosine-triphosphate (ATP) production in tumor cells and driving the Warburg effect.
Ailin Qiu, Xiaosha Wen, Qingshuang Zou, Lei Yin, Siqi Zhu, Yao Sheng, Yan He, Quan Liu, Dixian Luo, Zifen Guo   +9 more
doaj   +1 more source

Zamojskie PGK chlubą miasta

Barometr Regionalny, 2002
Waldemar Kaźmierczak
doaj   +1 more source

AT‐AER: Adversarial Training With Adaptive Example Reuse

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Adversarial training (AT) is widely regarded as a crucial defense method for deep neural networks against adversarial attacks. Most of the existing AT methods suffer from the problems of insufficient coverage of perturbation space and robust overfitting.
Meng Hu, Yanting Guo, Ran Wang, Xizhao Wang, Rihao Li, Qin Wang   +5 more
wiley   +1 more source