Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea [PDF]
Open Biology, 2020 Phosphoglycerate kinase (PGK) is a glycolytic enzyme that is well conserved among the three domains of life. PGK is usually a monomeric enzyme of about 45 kDa that catalyses one of the two ATP-producing reactions in the glycolytic pathway, through the ...
Maura Rojas-Pirela +7 more
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Regulation of phosphoglycerate kinase 1 and its critical role in cancer [PDF]
Cell Communication and Signaling, 2023 Cells that undergo normal differentiation mainly rely on mitochondrial oxidative phosphorylation to provide energy, but most tumour cells rely on aerobic glycolysis. This phenomenon is called the "Warburg effect".
Kexin Zhang, Lixue Sun, Yuanyuan Kang
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Molecular characterization and analysis of the drug resistance-associated protein phosphoglycerate kinase of Eimeria tenella [PDF]
ParasitologyCoccidiosis is a parasitic disease caused by Eimeria spp., and the emergence of drug resistance has seriously affected the control of the disease.
Yu Yu +5 more
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The Phosphoglycerate Kinase (PGK) Gene Family of Maize (Zea mays var. B73) [PDF]
Plants, 2020 Phosphoglycerate kinase (PGK, E.C. 2.7.2.3) interconverts ADP + 1,3-bisphospho-glycerate (1,3-bPGA) to ATP + 3-phosphoglycerate (3PGA). While most bacteria have a single pgk gene and mammals possess two copies, plant genomes contain three or more PGK ...
Julio A. Massange-Sánchez +4 more
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Phosphoglycerate kinase 1 contributes to diabetic kidney disease through enzyme-dependent and independent manners [PDF]
Cell Reports MedicineSummary: Diabetic kidney disease (DKD) is characterized by abnormal metabolic profiles. Metabolomics reveals increased serum levels of 3-phosphoglycerate (3-PG) in DKD patients.
Hai-Jian Sun +13 more
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20-Hydroxyecdysone counteracts insulin to promote programmed cell death by modifying phosphoglycerate kinase 1 [PDF]
BMC Biology, 2023 Background The regulation of glycolysis and autophagy during feeding and metamorphosis in holometabolous insects is a complex process that is not yet fully understood.
Xin-Le Kang +4 more
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Phosphoglycerate kinase 1 as a potential prognostic biomarker in papillary thyroid carcinoma [PDF]
Frontiers in PharmacologyBackgroudPapillary thyroid carcinoma (PTC) represents a malignant epithelial tumor characterized with a preference for younger individuals. Despite its generally favorable prognosis, PTC still poses considerable challenges, particularly in regards to the
Xiao-Qing Shi +12 more
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Metabolic protein phosphoglycerate kinase 1 confers lung cancer migration by directly binding HIV Tat specific factor 1 [PDF]
Cell Death Discovery, 2021 Phosphoglycerate kinase (PGK) is involved in glycolytic and various metabolic events. Dysfunction of PGK may induce metabolic reprogramming and the Warburg effect.
Yu-Chan Chang +7 more
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Phosphoglycerate Kinase Is Involved in Carbohydrate Utilization, Extracellular Polysaccharide Biosynthesis, and Cell Motility of Xanthomonas axonopodis pv. glycines Independent of Clp [PDF]
Frontiers in Microbiology, 2020 Phosphoglycerate kinase (Pgk), catalyzing the reversible conversions between glycerate-1.3-2P and glycerate-3P, plays an important role in carbohydrate metabolism. Here, we show that a Pgk-deficient mutant (NΔpgk) of Xanthomonas axonopodis pv.
Wei Guo +7 more
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Effects of phosphoglycerate kinase 1 and pyruvate kinase M2 on metabolism and physiochemical changes in postmortem muscle [PDF]
Food Chemistry: XThe objective of this work was to investigate the influence of phosphoglycerate kinase-1 (PGK1) and pyruvate kinase-M2 (PKM2) activity on glycolysis, myofibrillar proteins, calpain system, and apoptosis pathways of postmortem muscle. The activity of PGK1
Caiyan Huang +7 more
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