Results 21 to 30 of about 31,695 (232)
Phosphoglycerate kinase acts as a futile cycle at high temperature [PDF]
, 2017 In (hyper)thermophilic organisms metabolic processes have to be adapted to function optimally at high temperature. We compared the gluconeogenic conversion of 3-phosphoglycerate via 1,3-bisphosphoglycerate to glyceraldehyde-3-phosphate at 30 C and at 70 ...
Snoep, J.L. +8 more
core +1 more source
BMC Evolutionary Biology, 2017 Background An important feature of eukaryotic evolution is metabolic compartmentalization, in which certain pathways are restricted to the cytosol or specific organelles. Glycolysis in eukaryotes is described as a cytosolic process.
Melania Abrahamian +3 more
doaj +1 more source
Age-related modifications in rat cardiac phosphoglycerate kinase. Rejuvenation of the old enzyme by unfolding-refolding [PDF]
, 1988 The occurrence of age-related modifications in functional and structural properties of several enzymes has been documented; however, the molecular basis of this phenomenon is still mostly unexplained.
Gafni, Ari, Zuniga, Alison
core +1 more source
O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle to promote tumor growth
Nature Communications, 2020 Post-translational modifications of phosphoglycerate kinase 1 (PGK1), a glycoytic enzyme, contribute to cancer progression. Here, the authors show that PGK1 is O-GlcNAcylated at T255, which induces its translocation into mitochondria to suppress the ...
Hao Nie +8 more
doaj +1 more source
Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism. [PDF]
, 1998 African trypanosomes compartmentalize glycolysis in a microbody, the glycosome. When growing in the mammalian bloodstream, trypanosomes contain only a rudimentary mitochondrion, and the first seven glycolytic enzymes, including phosphoglycerate kinase ...
Blattner, J +7 more
core +1 more source
Nature Communications, 2019 Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge.
Lai Wei +11 more
doaj +1 more source
Memorias do Instituto Oswaldo Cruz, 2015 Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
doaj +1 more source
Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1.
PLoS Biology, 2015 Phosphoglycerate kinase 1 (PGK1) catalyzes the reversible transfer of a phosphoryl group from 1, 3-bisphosphoglycerate (1, 3-BPG) to ADP, producing 3-phosphoglycerate (3-PG) and ATP. PGK1 plays a key role in coordinating glycolytic energy production with
Shiwen Wang +14 more
doaj +1 more source
Molecular insights on pathogenic effects of mutations causing phosphoglycerate kinase deficiency.
PLoS ONE, 2012 Phosphoglycerate kinase (PGK) catalyzes an important ATP-generating step in glycolysis. PGK1 deficiency is an uncommon X-linked inherited disorder, generally characterized by various combinations of non-spherocytic hemolytic anemia, neurological ...
Laurent R Chiarelli +6 more
doaj +1 more source
An allosteric signaling pathway of human 3-phosphoglycerate kinase from force distribution analysis. [PDF]
PLoS Computational Biology, 2014 3-Phosphogycerate kinase (PGK) is a two domain enzyme, which transfers a phosphate group between its two substrates, 1,3-bisphosphoglycerate bound to the N-domain and ADP bound to the C-domain.
Zoltan Palmai +3 more
doaj +1 more source