Results 101 to 110 of about 7,411,908 (274)

Scale invariant Volkov–Akulov supergravity

Physics Letters B, 2015
A scale invariant goldstino theory coupled to supergravity is obtained as a standard supergravity dual of a rigidly scale-invariant higher-curvature supergravity with a nilpotent chiral scalar curvature.
S. Ferrara, M. Porrati, A. Sagnotti
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Wissenschaftsorientierung von Dozierenden in der Lehrerinnen- und Lehrerbildung: Spielt die berufliche Laufbahn eine Rolle?

Schweizerische Zeitschrift für Bildungswissenschaften
Hochschuldozierende beeinflussen massgeblich die Kompetenzentwicklung angehender Lehrpersonen und sollen sowohl berufspraktisch als auch wissenschaftlich qualifiziert sein.
Melanie Elderton, Falk Scheidig, Annette Tettenborn   +2 more
doaj   +1 more source

POSSIBILITIES OF INITIAL ESTIMATION AND FURTHER VALIDATION OF INSIDE CONTROL RISK [PDF]

The approach option of the theme of this essay had in mind the distinguished importance of the objective of inside control regarding the segmentation with maximum exigency of the risks which can disadvantageously influence the fulfillment of the entity ...
Anca Ciumag Ph. D Student, Prof. Constantin Staicu Ph. D, Prof. Magdalena Mihai Ph. D   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A systematic review of shared decision making training programs for general practitioners

BMC Medical Education
Background Shared decision making (SDM) has been presented as the preferred approach for decisions where there is more than one acceptable option and has been identified a priority feature of high-quality patient-centered care. Considering the foundation
Jasmien Jaeken, Cathoo Billiouw, Lien Mertens, Pieter Van Bostraeten, Geertruida Bekkering, Mieke Vermandere, Bert Aertgeerts, Laura van Mileghem, Nicolas Delvaux   +8 more
doaj   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Flexibilisierung der Studienanforderungen in der Lehrerinnen- und Lehrerbildung – Was sagen Studieninteressierte und Studierende?

Beiträge zur Lehrerinnen- und Lehrerbildung
Ausgehend von der Annahme, dass eine höhere Flexibilität bei der Erfüllung der Studienanforderungen zu mehr Attraktivität der Lehrerinnen- und Lehrerbildung und zu besserer Studierbarkeit beitragen kann, werden in diesem Beitrag Äusserungen von ...
Philipp Emanuel Hirsch, Monika Holmeier, Carsten Quesel   +2 more
doaj   +1 more source