Results 121 to 130 of about 7,285,451 (331)

Context Driven Concept Based Image Retrieval

open access: yesInternational Journal of Information Science and Management, 2012
Several semantic image search schemes have been recently proposed to retrieve images from the web. However, the query context is regularly ignored in these techniques and hence, many of the returned images are not adequately relevant.
H. Vahdatnejad   +3 more
doaj  

Chern-Simons Theory with Sources and Dynamical Quantum Groups I: Canonical Analysis and Algebraic Structures

open access: yes, 2005
We study the quantization of Chern-Simons theory with group $G$ coupled to dynamical sources. We first study the dynamics of Chern-Simons sources in the Hamiltonian framework.
Buffenoir, E., Roche, Ph.
core   +2 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Biología molecular, una herramienta para la bioprospección del metabolismo secundario de plantas en Colombia Ejemplo práctico en plantas colombianas de interés medicinal

open access: yesRevista Colombiana de Biotecnología, 2004
Los metabolitos secundarios producidos por las plantas están involucrados en una multitud de interacciones ecológicas, entre ellas las interacciones planta-planta, planta-microorganismos, planta-animales y planta-insectos.
Natalia Palacios Rojas   +2 more
doaj  

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

Holistic forecasting for future pandemics: a review of pathogens, models, and data

open access: yesDiscover Public Health
Pandemics challenge the capacity and resilience of healthcare systems around the world. A rapid and effective response to the sudden spread of a pathogen is therefore key to minimising the burden of a disease.
Luis Roger Esquivel Gomez   +9 more
doaj   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

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