Results 121 to 130 of about 7,599,404 (323)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Biología molecular, una herramienta para la bioprospección del metabolismo secundario de plantas en Colombia Ejemplo práctico en plantas colombianas de interés medicinal

Revista Colombiana de Biotecnología, 2004
Los metabolitos secundarios producidos por las plantas están involucrados en una multitud de interacciones ecológicas, entre ellas las interacciones planta-planta, planta-microorganismos, planta-animales y planta-insectos.
Natalia Palacios Rojas, Daniel Burtin, Mark Leech   +2 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification

, 2012
Meike Stumpp, Marian Y. Hu, Frank Melzner, Magdalena A. Gutowska, Narimane Dorey, Nina Himmerkus, Wiebke C. Holtmann, Sam Dupont, Michael C. Thorndyke, Markus Bleich   +9 more
openalex   +2 more sources

Mitochondrial dysfunction and cytoskeletal disruption during chemical hypoxia to cultured rat hepatic sinusoidal endothelial cells: The pH paradox and cytoprotection by glucose, acidotic pH, and glycine [PDF]

, 1998
Y Nishimura, Lewis H. Romer, John J. Lemasters   +2 more
openalex   +1 more source

Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme

, 2022
L.G. Iacovino, Martina Rossi, Giuseppina Di Stefano, Valentina Rossi, Claudia Binda, Maurizio Brigotti, Fabio Tomaselli, Alberto Pietro Pasti, Fabrizio Dal Piaz, Stefano Cerini, Alejandro Hochkoeppler   +10 more
openalex   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Holistic forecasting for future pandemics: a review of pathogens, models, and data

Discover Public Health
Pandemics challenge the capacity and resilience of healthcare systems around the world. A rapid and effective response to the sudden spread of a pathogen is therefore key to minimising the burden of a disease.
Luis Roger Esquivel Gomez, Nadezdha Malysheva, Juliane Pfeil, Zewen Yang, Sandra M. Bütow, Christopher Irrgang, Nils Körber, Georges Hattab, Denise Kühnert, Katharina Ladewig   +9 more
doaj   +1 more source

The Interaction of Heparin Tetrasaccharides with Chemokine CCL5 Is Modulated by Sulfation Pattern and pH [PDF]

, 2015
Arunima Singh, Warren C. Kett, India C. Severin, Isaac Agyekum, Jiana Duan, I. Jonathan Amster, Amanda E. I. Proudfoot, Deirdre R. Coombe, Robert J. Woods   +8 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source