Results 131 to 140 of about 7,386,473 (331)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Biología molecular, una herramienta para la bioprospección del metabolismo secundario de plantas en Colombia Ejemplo práctico en plantas colombianas de interés medicinal

Revista Colombiana de Biotecnología, 2004
Los metabolitos secundarios producidos por las plantas están involucrados en una multitud de interacciones ecológicas, entre ellas las interacciones planta-planta, planta-microorganismos, planta-animales y planta-insectos.
Natalia Palacios Rojas, Daniel Burtin, Mark Leech   +2 more
doaj  

Simultaneous Determination of pH, CO2 Content, and Cell Volume in 0.1 ml. Aliquots of Cutaneous Blood [PDF]

, 1955
Richard B Singer, Jane Shohl, Dolores B Bluemle   +2 more
openalex   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Holistic forecasting for future pandemics: a review of pathogens, models, and data

Discover Public Health
Pandemics challenge the capacity and resilience of healthcare systems around the world. A rapid and effective response to the sudden spread of a pathogen is therefore key to minimising the burden of a disease.
Luis Roger Esquivel Gomez, Nadezdha Malysheva, Juliane Pfeil, Zewen Yang, Sandra M. Bütow, Christopher Irrgang, Nils Körber, Georges Hattab, Denise Kühnert, Katharina Ladewig   +9 more
doaj   +1 more source

Sempervirine from Gelsemium Root**Presented to Scientific Section, A. Ph. A., San Francisco. [PDF]

, 1915
A.E. Stevenson, L.E. Sayre
openalex   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

The Relative Action of Preservatives in Pharmaceutical Preparations**Read before Section on Practical Pharmacy and Dispensing, A. Ph. A., New Orleans meeting, 1921 [PDF]

, 1921
L.F. Gabel
openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Zeitgemässe Lehrkompetenzentwicklung

Zeitschrift für Hochschulentwicklung
Die Hochschullehre steht vor großen Herausforderungen: Digitalisierung, Bildungsexpansion und der Ruf nach guter, wissenschaftlich fundierter und gleichzeitig arbeitsmarktnaher Lehre verlangen nach neuen Ansätzen.
Marion Lehner, Angela Jochum, Benno Volk, Philip Barth, Samuel Krattenmacher   +4 more
doaj   +1 more source