Results 61 to 70 of about 7,285,451 (331)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Journal of Experimental Orthopaedics, 2023 Purpose Robotic‐assisted total knee arthroplasty typically necessitates use of tracking pins, which can vary in diameter. Complications such as infections and fractures at the pin‐site have been observed, but clarification of the effect of pin diameter ...
Sohil S. Desai +7 more
doaj +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
FEBS Letters, EarlyView.TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling +4 more
wiley +1 more source
Gender, 2015 Der Beitrag geht der Frage nach, wie im Deutsch- und Mathematikunterricht einer integrativen achten Klasse einer nicht-gymnasialen Schulform Leistung konstruiert und von peerkulturellen, geschlechtsbezogenen Formen überlagert wird.
Tanja Sturm, Monika Wagner-Willi
doaj +1 more source
Die Wirksamkeit von Lehrer*innenfortbildung aus der Sicht der Fortbildner*innen
Herausforderung Lehrer*innenbildung, 2020 Dieser Beitrag thematisiert die Wirksamkeit von Lehrer*innenfortbildungen sowie wahrgenommene Erwartungen aus der Perspektive der Fortbildner*innen. Die spärliche Forschungslage zu diesem Thema führte zu der Projektidee, den Fokus der Forschung auf die ...
Isabel Wanitschek +3 more
doaj +1 more source
On finite-volume gauge theory partition functions [PDF]
, 2000 We prove a Mahoux–Mehta-type theorem for finite-volume partition functions of SU(Nc≥3) gauge theories coupled to fermions in the fundamental representation. The large-volume limit is taken with the constraint V1/mπ4. The theorem allows one to express any
Akemann, G, Damgaard, PH
core +2 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
Designing an educational software of mathematics for elementary school students from the point of view of constructivism and its effectiveness [PDF]
فصلنامه نوآوریهای آموزشی, 2004 This investigation studies the view of constructivism computer-based education. The purpose of this study was to produce mathematics educational software based on constructivism and studies its effectiveness with two randomly chosen groups of subjects ...
Mostafa Sheykhzadeh +1 more
doaj
A continuous low star formation rate in IZw 18 ?
, 2000 Deep long-slit spectroscopic observations of the blue compact galaxy IZw 18 obtained with the CFH 3.6 m Telescope are presented. The very low value of oxygen abundance previously reported is confirmed and a very homogeneous abundance distribution is ...
Kunth, D. +4 more
core +2 more sources