Results 71 to 80 of about 7,386,473 (331)

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Die Wirksamkeit von Lehrer*innenfortbildung aus der Sicht der Fortbildner*innen

Herausforderung Lehrer*innenbildung, 2020
Dieser Beitrag thematisiert die Wirksamkeit von Lehrer*innenfortbildungen sowie wahrgenommene Erwartungen aus der Perspektive der Fortbildner*innen. Die spärliche Forschungslage zu diesem Thema führte zu der Projektidee, den Fokus der Forschung auf die ...
Isabel Wanitschek, Tamara Katschnig, Martin Auferbauer, Judith Prorok   +3 more
doaj   +1 more source

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Decoherence induced continuous pointer states [PDF]

, 2002
We investigate the reduced dynamics in the Markovian approximation of an infinite quantum spin system linearly coupled to a phonon field at positive temperature. The achieved diagonalization leads to a selection of the continuous family of pointer states
Blanchard, Ph., Olkiewicz, R.
core   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

PENGEMBANGAN SMK MODEL UNTUK MASA DEPAN

Cakrawala Pendidikan: Jurnal Ilmiah Pendidikan, 2013
Abstrak: Praktik penyelenggaraan SMK di Indonesia saat ini menunjukkan kelemahan-kelemahan sebagai berikut: menyelenggarakan fungsi tunggal, yaitu menyiapkan siswa untuk bekerja, untuk menjadi karyawan, dan kurang menyiapkan untuk menjadi wirausahawan ...
Slamet PH PH
doaj   +1 more source

A comparison of pin site complications between large and small pin diameters in robotic‐assisted total knee arthroplasty

Journal of Experimental Orthopaedics, 2023
Purpose Robotic‐assisted total knee arthroplasty typically necessitates use of tracking pins, which can vary in diameter. Complications such as infections and fractures at the pin‐site have been observed, but clarification of the effect of pin diameter ...
Sohil S. Desai, Jennifer A. Kunes, Michael B. Held, Mark Ren, Alirio J. deMeireles, Jeffrey A. Geller, Roshan P. Shah, H. John Cooper   +7 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Editorial 04/2024: Digitalität, Produktion, Verantwortung

Medienimpulse
Digitalisierung und Digitalität haben sich als neue gesamtgesellschaftliche Phänomene etabliert und werden in der (medienpädagogischen) Fachliteratur richtigerweise als solche verhandelt und analysiert.
Alessandro Barberi, Florian Danhel, Thomas Ballhausen, Klaus Himpsl-Gutermann   +3 more
doaj   +1 more source