Results 71 to 80 of about 7,411,908 (274)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Transformatives Lernen im Hochschulkontext

Zeitschrift für Hochschulentwicklung
Angesichts zunehmender sozialer Ungleichheit sowie der Auswirkungen von Umweltzerstörung und Klimawandel stehen Hochschulen in der Verantwortung, zur Bewältigung dieser Herausforderungen beizutragen.
Ingrid Geier, Robert Hummer, Sandra Milz, Alessandro Barberi   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Editorial 04/2024: Digitalität, Produktion, Verantwortung

Medienimpulse
Digitalisierung und Digitalität haben sich als neue gesamtgesellschaftliche Phänomene etabliert und werden in der (medienpädagogischen) Fachliteratur richtigerweise als solche verhandelt und analysiert.
Alessandro Barberi, Florian Danhel, Thomas Ballhausen, Klaus Himpsl-Gutermann   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Die Wirksamkeit von Lehrer*innenfortbildung aus der Sicht der Fortbildner*innen

Herausforderung Lehrer*innenbildung, 2020
Dieser Beitrag thematisiert die Wirksamkeit von Lehrer*innenfortbildungen sowie wahrgenommene Erwartungen aus der Perspektive der Fortbildner*innen. Die spärliche Forschungslage zu diesem Thema führte zu der Projektidee, den Fokus der Forschung auf die ...
Isabel Wanitschek, Tamara Katschnig, Martin Auferbauer, Judith Prorok   +3 more
doaj   +1 more source

The Ph Paradox

Science of The Total Environment
This paper highlights the critical role of pH or proton activity measurements in environmental studies and emphasises the importance of applying proper statistical approaches when handling pH data. This allows for more informed decisions to effectively manage environmental data such as from mining influenced water.
Kagiso Samuel More, Christian Wolkersdorfer   +1 more
openaire   +2 more sources

X-rays from Quiescent Low-Mass X-ray Binary Transients

, 2000
I argue that it is very unlikely that X-rays from quiescent black-hole low-mass X-ray binary transients are emitted by coronae of companion stars. I show that in a simple model in which these X-rays are emitted by an ADAF filling the inner part of an ...
Lasota, Jean-Pierre
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source